TY - JOUR
T1 - Characterization of the Manila family of Mycobacterium tuberculosis
AU - Douglas, James T.
AU - Qian, Lishi
AU - Montoya, Jaime C.
AU - Musser, James M.
AU - Van Embden, Jan D.A.
AU - Van Soolingen, Dick
AU - Kremer, Kristin
PY - 2003/6/1
Y1 - 2003/6/1
N2 - Forty-eight Mycobacterium tuberculosis strains were obtained from patients living in metropolitan Manila, Republic of the Philippines. Three molecular typing methods, IS6110 restriction fragment length polymorphism, spoligotyping, and DNA sequencing of the oxyR, gyrA, and katG loci, established that these strains have restricted diversity and are members of a related genetic group of organisms. Comparison of the DNA fingerprint patterns with those in international databases confirmed the uniqueness of this group of isolates, which we designate the Manila family of M. tuberculosis.
AB - Forty-eight Mycobacterium tuberculosis strains were obtained from patients living in metropolitan Manila, Republic of the Philippines. Three molecular typing methods, IS6110 restriction fragment length polymorphism, spoligotyping, and DNA sequencing of the oxyR, gyrA, and katG loci, established that these strains have restricted diversity and are members of a related genetic group of organisms. Comparison of the DNA fingerprint patterns with those in international databases confirmed the uniqueness of this group of isolates, which we designate the Manila family of M. tuberculosis.
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U2 - 10.1128/JCM.41.6.2723-2726.2003
DO - 10.1128/JCM.41.6.2723-2726.2003
M3 - Article
C2 - 12791915
AN - SCOPUS:0038519130
SN - 0095-1137
VL - 41
SP - 2723
EP - 2726
JO - Journal of Clinical Microbiology
JF - Journal of Clinical Microbiology
IS - 6
ER -