Characterization of the Manila family of Mycobacterium tuberculosis

James T. Douglas, Lishi Qian, Jaime C. Montoya, James M. Musser, Jan D.A. Van Embden, Dick Van Soolingen, Kristin Kremer

Research output: Contribution to journalArticlepeer-review

55 Scopus citations


Forty-eight Mycobacterium tuberculosis strains were obtained from patients living in metropolitan Manila, Republic of the Philippines. Three molecular typing methods, IS6110 restriction fragment length polymorphism, spoligotyping, and DNA sequencing of the oxyR, gyrA, and katG loci, established that these strains have restricted diversity and are members of a related genetic group of organisms. Comparison of the DNA fingerprint patterns with those in international databases confirmed the uniqueness of this group of isolates, which we designate the Manila family of M. tuberculosis.

Original languageEnglish (US)
Pages (from-to)2723-2726
Number of pages4
JournalJournal of Clinical Microbiology
Issue number6
StatePublished - Jun 1 2003

ASJC Scopus subject areas

  • Microbiology (medical)


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