TY - JOUR
T1 - Characterization of the immune response to collagen-like proteins Scl1 and Scl2 of serotype M1 and M28 group a Streptococcus
AU - Hoe, Nancy P.
AU - Lukomska, Ewa
AU - Musser, James M.
AU - Lukomski, Slawomir
PY - 2007/12
Y1 - 2007/12
N2 - Group A Streptococcus (GAS) infections may trigger autoimmune sequelae thought to involve streptococcal antibodies cross-reactive to human antigens. Here, the antigenicity of the streptococcal collagen-like (CL) proteins, Scl1 and Scl2, that exhibit structural similarity to human collagen, was analyzed. Antibodies to Scl1.1 protein were detected in human sera from healthy individuals previously infected with M1 GAS and from patients with various GAS infections, as well as in sera from mice infected with M1 GAS. Linear B-cell epitope mapping identified immunoreactive peptides corresponding to the CL region of Scl1.1. Humoral responses to Scl1.28 and Scl2.28 were also detected in pediatric patients and mice infected with M28 GAS.
AB - Group A Streptococcus (GAS) infections may trigger autoimmune sequelae thought to involve streptococcal antibodies cross-reactive to human antigens. Here, the antigenicity of the streptococcal collagen-like (CL) proteins, Scl1 and Scl2, that exhibit structural similarity to human collagen, was analyzed. Antibodies to Scl1.1 protein were detected in human sera from healthy individuals previously infected with M1 GAS and from patients with various GAS infections, as well as in sera from mice infected with M1 GAS. Linear B-cell epitope mapping identified immunoreactive peptides corresponding to the CL region of Scl1.1. Humoral responses to Scl1.28 and Scl2.28 were also detected in pediatric patients and mice infected with M28 GAS.
KW - Group A Streptococcus
KW - Humoral response
KW - Scl
UR - http://www.scopus.com/inward/record.url?scp=36348951944&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=36348951944&partnerID=8YFLogxK
U2 - 10.1111/j.1574-6968.2007.00955.x
DO - 10.1111/j.1574-6968.2007.00955.x
M3 - Article
C2 - 18031333
AN - SCOPUS:36348951944
VL - 277
SP - 142
EP - 149
JO - FEMS Microbiology Letters
JF - FEMS Microbiology Letters
SN - 0378-1097
IS - 2
ER -