Characterization of the immune response to collagen-like proteins Scl1 and Scl2 of serotype M1 and M28 group a Streptococcus

Nancy P. Hoe, Ewa Lukomska, James M. Musser, Slawomir Lukomski

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Group A Streptococcus (GAS) infections may trigger autoimmune sequelae thought to involve streptococcal antibodies cross-reactive to human antigens. Here, the antigenicity of the streptococcal collagen-like (CL) proteins, Scl1 and Scl2, that exhibit structural similarity to human collagen, was analyzed. Antibodies to Scl1.1 protein were detected in human sera from healthy individuals previously infected with M1 GAS and from patients with various GAS infections, as well as in sera from mice infected with M1 GAS. Linear B-cell epitope mapping identified immunoreactive peptides corresponding to the CL region of Scl1.1. Humoral responses to Scl1.28 and Scl2.28 were also detected in pediatric patients and mice infected with M28 GAS.

Original languageEnglish (US)
Pages (from-to)142-149
Number of pages8
JournalFEMS Microbiology Letters
Volume277
Issue number2
DOIs
StatePublished - Dec 2007

Keywords

  • Group A Streptococcus
  • Humoral response
  • Scl

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Applied Microbiology and Biotechnology
  • Microbiology

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