Characterization of somatically acquired ecotropic and mink cell focus-forming viruses in lymphomas of AKXD recombinant inbred mice

M. L. Mucenski, B. A. Taylor, N. G. Copeland, N. A. Jenkins

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

The DNA of lymphomas from 12 AKXD recombinant inbred mouse strains was analyzed to determine the presence of somatically acquired ecotropic and mink cell focus-forming proviruses. Mink cell focus-forming proviruses were associated primarily with T-cel lymphomas, whereas ecotropic proviruses were associated with lymphomas of B-cell and myeloid lineages. A model based on the results is proposed to explain the variation in lymphoma types observed in different AKXD strains.

Original languageEnglish (US)
Pages (from-to)2929-2933
Number of pages5
JournalJournal of virology
Volume61
Issue number9
DOIs
StatePublished - 1987

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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