TY - GEN
T1 - Characterization of polymer coated magnetic nanoparticles for targeted treatment of cancer
AU - Nattama, Sivaniaravindapriya
AU - Rahimi, Maham
AU - Wadajkar, Aniket S.
AU - Koppolu, Bhanuprasanth
AU - Hua, Jennifer
AU - Nwariaku, Fiemu
AU - Nguyen, Kytai T.
PY - 2007
Y1 - 2007
N2 - The objective of this project is to develop and characterize a targeted drug delivery vehicle capable of the controlled release of chemotherapy to treat malignant tumors. Our construct consists of a magnetic core with a thermosensitive polymer (N-isopropylacrylamide, NIPA) shell. The advantage of this system is that a magnetic field can be used for targeting the construct as well as to induce heat for hyperthermia treatment. Furthermore, the drug can be loaded into the NIPA layer and released when the temperature reaches its lower critical solution temperature (LCST). Drug release studies were used to characterize the thermoresponsive properties of the construct. Cellular uptake and cytotoxicity studies were also performed to determine in vitro behavior. Our NIPA-magnetic nanoparticle presents a unique and effective method of treating many cancers while reducing the deleterious effects associated with traditional drug delivery methods.
AB - The objective of this project is to develop and characterize a targeted drug delivery vehicle capable of the controlled release of chemotherapy to treat malignant tumors. Our construct consists of a magnetic core with a thermosensitive polymer (N-isopropylacrylamide, NIPA) shell. The advantage of this system is that a magnetic field can be used for targeting the construct as well as to induce heat for hyperthermia treatment. Furthermore, the drug can be loaded into the NIPA layer and released when the temperature reaches its lower critical solution temperature (LCST). Drug release studies were used to characterize the thermoresponsive properties of the construct. Cellular uptake and cytotoxicity studies were also performed to determine in vitro behavior. Our NIPA-magnetic nanoparticle presents a unique and effective method of treating many cancers while reducing the deleterious effects associated with traditional drug delivery methods.
UR - http://www.scopus.com/inward/record.url?scp=48949118128&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=48949118128&partnerID=8YFLogxK
U2 - 10.1109/EMBSW.2007.4454167
DO - 10.1109/EMBSW.2007.4454167
M3 - Conference contribution
AN - SCOPUS:48949118128
SN - 9781424416264
T3 - 2007 IEEE Dallas Engineering in Medicine and Biology Workshop, DEMBS
SP - 35
EP - 38
BT - 2007 IEEE Dallas Engineering in Medicine and Biology Workshop, DEMBS
T2 - 2007 IEEE Dallas Engineering in Medicine and Biology Workshop, DEMBS
Y2 - 11 November 2007 through 12 November 2007
ER -