Characterization of interlimb interaction via transcutaneous spinal stimulation of cervical and lumbar spinal enlargements

D. A. Atkinson, A. G. Steele, G. A. Manson, J. Sheynin, J. Oh, Y. P. Gerasimenko, D. G. Sayenko

Research output: Contribution to journalArticlepeer-review

Abstract

The use of transcutaneous electrical spinal stimulation (TSS) to modulate sensorimotor networks after neurological insult has garnered much attention from both researchers and clinicians in recent years. Although many different stimulation paradigms have been reported, the interlimb effects of these neuromodulation techniques have been little studied. The effects of multisite TSS on interlimb sensorimotor function are of particular interest in the context of neurorehabilitation, as these networks have been shown to be important for functional recovery after neurological insult. The present study utilized a condition-test paradigm to investigate the effects of interenlargement TSS on spinal motor excitability in both cervical and lumbosacral motor pools. Additionally, comparison was made between the conditioning effects of lumbosacral and cervical TSS and peripheral stimulation of the fibular nerve and ulnar nerve, respectively. In 16/16 supine, relaxed participants, facilitation of spinally evoked motor responses (sEMRs) in arm muscles was seen in response to lumbosacral TSS or fibular nerve stimulation, whereas facilitation of sEMRs in leg muscles was seen in response to cervical TSS or ulnar nerve stimulation. The decreased latency between TSSand peripheral nerve-evoked conditioning implicates interlimb networks in the observed facilitation of motor output. The results demonstrate the ability of multisite TSS to engage interlimb networks, resulting in the bidirectional influence of cervical and lumbosacral motor output. The engagement of interlimb networks via TSS of the cervical and lumbosacral enlargements represents a feasible method for engaging spinal sensorimotor networks in clinical populations with compromised motor function.

Original languageEnglish (US)
Pages (from-to)1075-1085
Number of pages11
JournalJournal of Neurophysiology
Volume127
Issue number4
DOIs
StatePublished - Apr 2022

Keywords

  • human neurophysiology
  • interlimb reflexes
  • propriospinal
  • spinal cord
  • transcutaneous spinal stimulation
  • Spinal Cord Injuries
  • Transcutaneous Electric Nerve Stimulation/methods
  • Humans
  • Muscle, Skeletal/physiology
  • Spinal Cord/physiology
  • Spinal Cord Stimulation/methods

ASJC Scopus subject areas

  • Physiology
  • Neuroscience(all)

Fingerprint

Dive into the research topics of 'Characterization of interlimb interaction via transcutaneous spinal stimulation of cervical and lumbar spinal enlargements'. Together they form a unique fingerprint.

Cite this