TY - JOUR
T1 - Characterization of ceftriaxone-resistant enterobacteriaceae
T2 - A multicentre study in 26 french hospitals
AU - Goldstein, F. W.
AU - Péan, Y.
AU - Rosato, A.
AU - Gertner, J.
AU - Gutmann, L.
N1 - Funding Information:
This study was supported by Produits Roche, France. We thank Monique Boda for secretarial assistance.
Copyright:
Copyright 2010 Elsevier B.V., All rights reserved.
PY - 1993/10
Y1 - 1993/10
N2 - During a multicentre study performed in 26 French hospitals, 287 (3·2%) of 9038 Enterobacteriaceac isolated, mainly Enterobacter spp., Serratia spp., Citrobacter spp. and Kiebsiella spp. were classified as ceftriaxone resistant on the basis of an MIC >4 mg/L or the presence of an extended-spectrum β-lactamase. Extended-spectrum β-lactamase was present mainly in Kiebsiella pneumoniae (65 strains, 10·2%) and very rarely in Escherichia coli, Proteus mirabilis, Klebsiella oxytoca, Citrobacter spp. and Enterobacter spp. The extended-spectrum β-lacta mases conferred low-level resistance to ceftriaxone in nearly 60% of the strains harbouring them, emphasizing the need for routine testing for the presence of these enzymes. Among transconjugants three types of extended-spectrum β-lactamase were identified. Those resembling TEM-3 were the most common, but TEM-21, and SHV-4 were also found. Clavulanate and to a lesser extent sulbactam inhibited all the extended-spectrum β-lactamases encountered in this study.
AB - During a multicentre study performed in 26 French hospitals, 287 (3·2%) of 9038 Enterobacteriaceac isolated, mainly Enterobacter spp., Serratia spp., Citrobacter spp. and Kiebsiella spp. were classified as ceftriaxone resistant on the basis of an MIC >4 mg/L or the presence of an extended-spectrum β-lactamase. Extended-spectrum β-lactamase was present mainly in Kiebsiella pneumoniae (65 strains, 10·2%) and very rarely in Escherichia coli, Proteus mirabilis, Klebsiella oxytoca, Citrobacter spp. and Enterobacter spp. The extended-spectrum β-lacta mases conferred low-level resistance to ceftriaxone in nearly 60% of the strains harbouring them, emphasizing the need for routine testing for the presence of these enzymes. Among transconjugants three types of extended-spectrum β-lactamase were identified. Those resembling TEM-3 were the most common, but TEM-21, and SHV-4 were also found. Clavulanate and to a lesser extent sulbactam inhibited all the extended-spectrum β-lactamases encountered in this study.
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U2 - 10.1093/jac/32.4.595
DO - 10.1093/jac/32.4.595
M3 - Article
C2 - 8288501
AN - SCOPUS:0027489906
VL - 32
SP - 595
EP - 603
JO - Journal of Antimicrobial Chemotherapy
JF - Journal of Antimicrobial Chemotherapy
SN - 0305-7453
IS - 4
ER -