Characterization of arterial wave propagation and reflection in mice

Craig J. Hartley, Anil K. Reddy, Sridhar Madala, Mark L. Entman, Lloyd H. Michael, George Taffet

Research output: Chapter in Book/Report/Conference proceedingConference contribution

6 Scopus citations

Abstract

Wave propagation through the arterial system changes with age and disease state, and mutant mice are often used to study these conditions. We have developed several noninvasive ultrasonic techniques to measure blood velocity and vessel wall motion from which we can calculate aortic pulse wave velocity (PWV), local compliance, impedance spectra, characteristic impedance (Z c), augmentation index (AI), and forward and backward waves in intact anesthetized mice. We found altered vascular mechanics in many mutant strains of mice. In old mice PWV, AI, and Zc are increased. In atherosclerotic mice PWV, Zc, and AI are increased; peripheral resistance and arterial compliance are decreased; and wave reflections are enhanced. We find that the initial deceleration of carotid velocity is caused by peripheral reflections, and that increased acceleration of velocity in the aortic arch in atherosclerotic mice is caused by enhanced carotid reflections returning to the heart and traveling forward in the aorta. We conclude that when scaled for heart period, the mouse arterial system and its responses to age and disease are similar to those in man. The ability to evaluate arterial mechanics in mice will expand their use as models to study human arterial diseases and conditions.

Original languageEnglish (US)
Title of host publicationProceedings of the 2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages601-604
Number of pages4
ISBN (Print)0780387406, 9780780387409
DOIs
StatePublished - 2005
Event2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005 - Shanghai, China
Duration: Sep 1 2005Sep 4 2005

Publication series

NameAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume7 VOLS
ISSN (Print)0589-1019

Other

Other2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005
CountryChina
CityShanghai
Period9/1/059/4/05

Keywords

  • Arterial mechanics
  • Blood velocity
  • Carotid artery
  • Doppler displacement
  • Wave reflections

ASJC Scopus subject areas

  • Bioengineering

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