Characterization of adrenergic receptors in the accessory lacrimal glands of the upper eyelid

Purpose: To identify the histologic location as well as the exact subtype of adrenergic receptors in the accessory lacrimal glands of the upper eyelid. Methods: Upper eyelid specimens were collected from 19 patients undergoing routine blepharoptosis correction via a posterior tarsoconjunctival mullerectomy. Immunohistochemical staining using polyclonal antibodies against human α1, α2, β1, and β2 receptors was performed on all specimens. Results: β1 receptors were the predominant adrenergic receptor subtype in the glands of Wolfring. Conclusions: The presence of β1 receptors in the accessory lacrimal glands of the upper eyelid may suggest a possible role for selective β1 agonists in the treatment of keratitis sicca.