Characterization of a novel immunocytolytic factor secreted by pancreatic adenocarcinoma

Celia M. Divino, Luz P. Angel, Steven T. Brower, Shu Hsia Chen

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

We observed a putative immunocytolytic factor secreted in the supernatant of several pancreatic adenocarcinoma cell lines that induces apoptosis in lymphocytes. A marked reduction in the viability of the target splenocytes was evident after co-incubation with the supernatants from various pancreatic adenocarcinoma cell lines (human, hamster, and murine). The immunocytolytic effect was not evident with the conditioned media of normal pancreatic duct epithelial cells or other nonpancreatic tumor cells. Biologic activity of the supernatants was determined to be heat sensitive and reside in a 30- to 50-kDa range. Immune and functional assays have excluded known immunosuppressive factors.

Original languageEnglish (US)
Pages (from-to)489-495
Number of pages7
JournalOncology Research
Volume11
Issue number11-12
StatePublished - 1999

Keywords

  • Apoptosis
  • Immunocytolytic factor
  • Lymphocytes
  • Pancreatic cancer

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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