Characterization and mapping of the rapsn gene encoding the 43-kDa acetylcholine receptor-associated protein

Medha Gautam; Jacqueline Mudd; Neal G. Copeland; Debra J. Gilbert; Nancy A. Jenkins; John P. Merlie

doi:10.1006/geno.1994.1629

Characterization and mapping of the rapsn gene encoding the 43-kDa acetylcholine receptor-associated protein

Medha Gautam, Jacqueline Mudd, Neal G. Copeland, Debra J. Gilbert, Nancy A. Jenkins, John P. Merlie

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

We have cloned and characterized mouse genomic DNA containing the gene for the 43-kDa acetylcholine receptor-associated protein. The gene extends over 12 kb and consists of 8 exons. RNase protection and sequence analysis have been used to define the intron/exon boundaries including 174 and 214 bp of 5' and 3' untranslated sequence in exons 1 and 8, respectively. Interestingly, the exon/intron organization is consistent with structural domains predicted from amino acid sequence conservation among 3 species of 43K. Finally, the 43K locus, designated Rapsn, has been mapped to the central region of mouse chromosome 2.

Original language	English (US)
Pages (from-to)	366-369
Number of pages	4
Journal	Genomics
Volume	24
Issue number	2
DOIs	https://doi.org/10.1006/geno.1994.1629
State	Published - Nov 15 1994

ASJC Scopus subject areas

Genetics

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title = "Characterization and mapping of the rapsn gene encoding the 43-kDa acetylcholine receptor-associated protein",

abstract = "We have cloned and characterized mouse genomic DNA containing the gene for the 43-kDa acetylcholine receptor-associated protein. The gene extends over 12 kb and consists of 8 exons. RNase protection and sequence analysis have been used to define the intron/exon boundaries including 174 and 214 bp of 5' and 3' untranslated sequence in exons 1 and 8, respectively. Interestingly, the exon/intron organization is consistent with structural domains predicted from amino acid sequence conservation among 3 species of 43K. Finally, the 43K locus, designated Rapsn, has been mapped to the central region of mouse chromosome 2.",

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AU - Gautam, Medha

AU - Mudd, Jacqueline

AU - Copeland, Neal G.

AU - Gilbert, Debra J.

AU - Jenkins, Nancy A.

AU - Merlie, John P.

PY - 1994/11/15

Y1 - 1994/11/15

N2 - We have cloned and characterized mouse genomic DNA containing the gene for the 43-kDa acetylcholine receptor-associated protein. The gene extends over 12 kb and consists of 8 exons. RNase protection and sequence analysis have been used to define the intron/exon boundaries including 174 and 214 bp of 5' and 3' untranslated sequence in exons 1 and 8, respectively. Interestingly, the exon/intron organization is consistent with structural domains predicted from amino acid sequence conservation among 3 species of 43K. Finally, the 43K locus, designated Rapsn, has been mapped to the central region of mouse chromosome 2.

AB - We have cloned and characterized mouse genomic DNA containing the gene for the 43-kDa acetylcholine receptor-associated protein. The gene extends over 12 kb and consists of 8 exons. RNase protection and sequence analysis have been used to define the intron/exon boundaries including 174 and 214 bp of 5' and 3' untranslated sequence in exons 1 and 8, respectively. Interestingly, the exon/intron organization is consistent with structural domains predicted from amino acid sequence conservation among 3 species of 43K. Finally, the 43K locus, designated Rapsn, has been mapped to the central region of mouse chromosome 2.

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JO - Genomics

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ER -

Characterization and mapping of the rapsn gene encoding the 43-kDa acetylcholine receptor-associated protein

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