Characterization and mapping of the rapsn gene encoding the 43-kDa acetylcholine receptor-associated protein

Medha Gautam, Jacqueline Mudd, Neal G. Copeland, Debra J. Gilbert, Nancy A. Jenkins, John P. Merlie

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

We have cloned and characterized mouse genomic DNA containing the gene for the 43-kDa acetylcholine receptor-associated protein. The gene extends over 12 kb and consists of 8 exons. RNase protection and sequence analysis have been used to define the intron/exon boundaries including 174 and 214 bp of 5' and 3' untranslated sequence in exons 1 and 8, respectively. Interestingly, the exon/intron organization is consistent with structural domains predicted from amino acid sequence conservation among 3 species of 43K. Finally, the 43K locus, designated Rapsn, has been mapped to the central region of mouse chromosome 2.

Original languageEnglish (US)
Pages (from-to)366-369
Number of pages4
JournalGenomics
Volume24
Issue number2
DOIs
StatePublished - Nov 15 1994

ASJC Scopus subject areas

  • Genetics

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