Characteristics of the mouse genomic histamine H1 receptor gene

Isao Inoue; Ichiro Taniuchi; Daisuke Kitamura; Nancy A. Jenkins; Debra J. Gilbert; Neal G. Copeland; Takeshi Watanabe

doi:10.1006/geno.1996.0441

Characteristics of the mouse genomic histamine H1 receptor gene

Isao Inoue, Ichiro Taniuchi, Daisuke Kitamura, Nancy A. Jenkins, Debra J. Gilbert, Neal G. Copeland, Takeshi Watanabe

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Abstract

We report here the molecular cloning of a mouse histamine H1 receptor gene. The protein deduced from the nucleotide sequence is composed of 488 amino acid residues with characteristic properties of GTP binding protein- coupled receptors. Our results suggest that the mouse histamine H1 receptor gene is a single locus, and no related sequences were detected. Interspecific backcross analysis indicated that the mouse histamine HI receptor gene (Hrh1) is located in the central region of mouse Chromosome 6 linked to microphthalmia (Mitfmi), ras-related fibrosarcoma oncogene 1 (Raf1), and ret proto-oncogene (Ret) in a region of homology with human chromosome 3p.

Original language	English (US)
Pages (from-to)	178-181
Number of pages	4
Journal	Genomics
Volume	36
Issue number	1
DOIs	https://doi.org/10.1006/geno.1996.0441
State	Published - Aug 15 1996

ASJC Scopus subject areas

Genetics

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title = "Characteristics of the mouse genomic histamine H1 receptor gene",

abstract = "We report here the molecular cloning of a mouse histamine H1 receptor gene. The protein deduced from the nucleotide sequence is composed of 488 amino acid residues with characteristic properties of GTP binding protein- coupled receptors. Our results suggest that the mouse histamine H1 receptor gene is a single locus, and no related sequences were detected. Interspecific backcross analysis indicated that the mouse histamine HI receptor gene (Hrh1) is located in the central region of mouse Chromosome 6 linked to microphthalmia (Mitfmi), ras-related fibrosarcoma oncogene 1 (Raf1), and ret proto-oncogene (Ret) in a region of homology with human chromosome 3p.",

author = "Isao Inoue and Ichiro Taniuchi and Daisuke Kitamura and Jenkins, \{Nancy A.\} and Gilbert, \{Debra J.\} and Copeland, \{Neal G.\} and Takeshi Watanabe",

note = "Funding Information: We thank Dr. Y. Horio and H. Fukui for their useful information about histamine H1R genes and J. Wang for useful advice. In chromosomal mapping, we thank Deborah A. Barnhart and Mary Barnstead for excellent technical assistance. This research was supported, in part, by the National Cancer Institute, DHHS, under contract with ABL. This study was also supported in part by a grant from the Ministry of Health and Welfare of Japan and by a grant from the Japan Research Foundation For Clinical Pharmacology. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.",

year = "1996",

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doi = "10.1006/geno.1996.0441",

language = "English (US)",

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AU - Inoue, Isao

AU - Taniuchi, Ichiro

AU - Kitamura, Daisuke

AU - Jenkins, Nancy A.

AU - Gilbert, Debra J.

AU - Copeland, Neal G.

AU - Watanabe, Takeshi

N1 - Funding Information: We thank Dr. Y. Horio and H. Fukui for their useful information about histamine H1R genes and J. Wang for useful advice. In chromosomal mapping, we thank Deborah A. Barnhart and Mary Barnstead for excellent technical assistance. This research was supported, in part, by the National Cancer Institute, DHHS, under contract with ABL. This study was also supported in part by a grant from the Ministry of Health and Welfare of Japan and by a grant from the Japan Research Foundation For Clinical Pharmacology. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.

PY - 1996/8/15

Y1 - 1996/8/15

N2 - We report here the molecular cloning of a mouse histamine H1 receptor gene. The protein deduced from the nucleotide sequence is composed of 488 amino acid residues with characteristic properties of GTP binding protein- coupled receptors. Our results suggest that the mouse histamine H1 receptor gene is a single locus, and no related sequences were detected. Interspecific backcross analysis indicated that the mouse histamine HI receptor gene (Hrh1) is located in the central region of mouse Chromosome 6 linked to microphthalmia (Mitfmi), ras-related fibrosarcoma oncogene 1 (Raf1), and ret proto-oncogene (Ret) in a region of homology with human chromosome 3p.

AB - We report here the molecular cloning of a mouse histamine H1 receptor gene. The protein deduced from the nucleotide sequence is composed of 488 amino acid residues with characteristic properties of GTP binding protein- coupled receptors. Our results suggest that the mouse histamine H1 receptor gene is a single locus, and no related sequences were detected. Interspecific backcross analysis indicated that the mouse histamine HI receptor gene (Hrh1) is located in the central region of mouse Chromosome 6 linked to microphthalmia (Mitfmi), ras-related fibrosarcoma oncogene 1 (Raf1), and ret proto-oncogene (Ret) in a region of homology with human chromosome 3p.

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Characteristics of the mouse genomic histamine H1 receptor gene

Abstract

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