Characteristics of the mouse genomic histamine H1 receptor gene

Isao Inoue, Ichiro Taniuchi, Daisuke Kitamura, Nancy A. Jenkins, Debra J. Gilbert, Neal G. Copeland, Takeshi Watanabe

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

We report here the molecular cloning of a mouse histamine H1 receptor gene. The protein deduced from the nucleotide sequence is composed of 488 amino acid residues with characteristic properties of GTP binding protein- coupled receptors. Our results suggest that the mouse histamine H1 receptor gene is a single locus, and no related sequences were detected. Interspecific backcross analysis indicated that the mouse histamine HI receptor gene (Hrh1) is located in the central region of mouse Chromosome 6 linked to microphthalmia (Mitfmi), ras-related fibrosarcoma oncogene 1 (Raf1), and ret proto-oncogene (Ret) in a region of homology with human chromosome 3p.

Original languageEnglish (US)
Pages (from-to)178-181
Number of pages4
JournalGenomics
Volume36
Issue number1
DOIs
StatePublished - Aug 15 1996

ASJC Scopus subject areas

  • Genetics

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