Abstract
We report here the molecular cloning of a mouse histamine H1 receptor gene. The protein deduced from the nucleotide sequence is composed of 488 amino acid residues with characteristic properties of GTP binding protein- coupled receptors. Our results suggest that the mouse histamine H1 receptor gene is a single locus, and no related sequences were detected. Interspecific backcross analysis indicated that the mouse histamine HI receptor gene (Hrh1) is located in the central region of mouse Chromosome 6 linked to microphthalmia (Mitfmi), ras-related fibrosarcoma oncogene 1 (Raf1), and ret proto-oncogene (Ret) in a region of homology with human chromosome 3p.
Original language | English (US) |
---|---|
Pages (from-to) | 178-181 |
Number of pages | 4 |
Journal | Genomics |
Volume | 36 |
Issue number | 1 |
DOIs | |
State | Published - Aug 15 1996 |
ASJC Scopus subject areas
- Genetics