Characteristics of the mouse genomic histamine H1 receptor gene

Isao Inoue; Ichiro Taniuchi; Daisuke Kitamura; Nancy A. Jenkins; Debra J. Gilbert; Neal G. Copeland; Takeshi Watanabe

doi:10.1006/geno.1996.0441

Characteristics of the mouse genomic histamine H1 receptor gene

Isao Inoue, Ichiro Taniuchi, Daisuke Kitamura, Nancy A. Jenkins, Debra J. Gilbert, Neal G. Copeland, Takeshi Watanabe

Research output: Contribution to journal › Article

34 Scopus citations

Abstract

We report here the molecular cloning of a mouse histamine H1 receptor gene. The protein deduced from the nucleotide sequence is composed of 488 amino acid residues with characteristic properties of GTP binding protein- coupled receptors. Our results suggest that the mouse histamine H1 receptor gene is a single locus, and no related sequences were detected. Interspecific backcross analysis indicated that the mouse histamine HI receptor gene (Hrh1) is located in the central region of mouse Chromosome 6 linked to microphthalmia (Mitfmi), ras-related fibrosarcoma oncogene 1 (Raf1), and ret proto-oncogene (Ret) in a region of homology with human chromosome 3p.

Original language	English (US)
Pages (from-to)	178-181
Number of pages	4
Journal	Genomics
Volume	36
Issue number	1
DOIs	https://doi.org/10.1006/geno.1996.0441
State	Published - Aug 15 1996

ASJC Scopus subject areas

Genetics

Access to Document

10.1006/geno.1996.0441

Fingerprint Dive into the research topics of 'Characteristics of the mouse genomic histamine H1 receptor gene'. Together they form a unique fingerprint.

Cite this

@article{42304b5cc9664e67869f4d5542b7a358,

title = "Characteristics of the mouse genomic histamine H1 receptor gene",

abstract = "We report here the molecular cloning of a mouse histamine H1 receptor gene. The protein deduced from the nucleotide sequence is composed of 488 amino acid residues with characteristic properties of GTP binding protein- coupled receptors. Our results suggest that the mouse histamine H1 receptor gene is a single locus, and no related sequences were detected. Interspecific backcross analysis indicated that the mouse histamine HI receptor gene (Hrh1) is located in the central region of mouse Chromosome 6 linked to microphthalmia (Mitfmi), ras-related fibrosarcoma oncogene 1 (Raf1), and ret proto-oncogene (Ret) in a region of homology with human chromosome 3p.",

author = "Isao Inoue and Ichiro Taniuchi and Daisuke Kitamura and Jenkins, {Nancy A.} and Gilbert, {Debra J.} and Copeland, {Neal G.} and Takeshi Watanabe",

year = "1996",

month = aug,

day = "15",

doi = "10.1006/geno.1996.0441",

language = "English (US)",

volume = "36",

pages = "178--181",

journal = "Genomics",

issn = "0888-7543",

publisher = "Academic Press",

number = "1",

}

TY - JOUR

T1 - Characteristics of the mouse genomic histamine H1 receptor gene

AU - Inoue, Isao

AU - Taniuchi, Ichiro

AU - Kitamura, Daisuke

AU - Jenkins, Nancy A.

AU - Gilbert, Debra J.

AU - Copeland, Neal G.

AU - Watanabe, Takeshi

PY - 1996/8/15

Y1 - 1996/8/15

N2 - We report here the molecular cloning of a mouse histamine H1 receptor gene. The protein deduced from the nucleotide sequence is composed of 488 amino acid residues with characteristic properties of GTP binding protein- coupled receptors. Our results suggest that the mouse histamine H1 receptor gene is a single locus, and no related sequences were detected. Interspecific backcross analysis indicated that the mouse histamine HI receptor gene (Hrh1) is located in the central region of mouse Chromosome 6 linked to microphthalmia (Mitfmi), ras-related fibrosarcoma oncogene 1 (Raf1), and ret proto-oncogene (Ret) in a region of homology with human chromosome 3p.

AB - We report here the molecular cloning of a mouse histamine H1 receptor gene. The protein deduced from the nucleotide sequence is composed of 488 amino acid residues with characteristic properties of GTP binding protein- coupled receptors. Our results suggest that the mouse histamine H1 receptor gene is a single locus, and no related sequences were detected. Interspecific backcross analysis indicated that the mouse histamine HI receptor gene (Hrh1) is located in the central region of mouse Chromosome 6 linked to microphthalmia (Mitfmi), ras-related fibrosarcoma oncogene 1 (Raf1), and ret proto-oncogene (Ret) in a region of homology with human chromosome 3p.

UR - http://www.scopus.com/inward/record.url?scp=0030586851&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030586851&partnerID=8YFLogxK

U2 - 10.1006/geno.1996.0441

DO - 10.1006/geno.1996.0441

M3 - Article

C2 - 8812432

AN - SCOPUS:0030586851

VL - 36

SP - 178

EP - 181

JO - Genomics

JF - Genomics

SN - 0888-7543

IS - 1

ER -