TY - JOUR
T1 - Changes in steroid hormone metabolism in rat liver microsomes following administration of 2,3,7,8-tetrachlorodibenzo-p-dioxine (TCDD)
AU - Gustafsson, Jan Åke
AU - Ingelman-Sundberg, Magnus
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 1979
Y1 - 1979
N2 - Treatment of male and female rats with 4 × 20 μg/kg of 2,3,7,8-tetrachlorodibenzo-p-dioxine (TCDD) led to 2-3-fold increases in liver microsomal cytochrome P450 levels concomitantly with changes in liver microsomal metabolism of 4-androstene-3,17-dione, 5α-androstane-3α,17β-diol and 4-pregnene-3, 20-dione. The changes were most pronounced in female rats where some hydroxylase activities increased 3-5-fold. It is suggested that the observed effects following TCDD administration may be related to the endocrine symptoms sometimes seen in patients exposed to this drug.
AB - Treatment of male and female rats with 4 × 20 μg/kg of 2,3,7,8-tetrachlorodibenzo-p-dioxine (TCDD) led to 2-3-fold increases in liver microsomal cytochrome P450 levels concomitantly with changes in liver microsomal metabolism of 4-androstene-3,17-dione, 5α-androstane-3α,17β-diol and 4-pregnene-3, 20-dione. The changes were most pronounced in female rats where some hydroxylase activities increased 3-5-fold. It is suggested that the observed effects following TCDD administration may be related to the endocrine symptoms sometimes seen in patients exposed to this drug.
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U2 - 10.1016/0006-2952(79)90242-9
DO - 10.1016/0006-2952(79)90242-9
M3 - Article
C2 - 426869
AN - SCOPUS:0018768667
SN - 0006-2952
VL - 28
SP - 497
EP - 499
JO - Biochemical pharmacology
JF - Biochemical pharmacology
IS - 4
ER -