Changes in in vivo metabolism of bile acids in rat after treatment with phenobarbital

Tomas Cronholm, Kurt Einarsson, Jan-Ake Gustafsson

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

The influence of phenobarbital on pool size and turnover of bile acids in rats have been investigated by administration of [24-14C] cholic acid and tritium labeled chenodeoxycholic acid. Phenobarbital treated rats had a smaller cholic acid pool compared to control rats (6.08±2.09 mg and 23.60±7.66 mg, respectively). The pool size of chenodeoxycholic acid, plus its metabolites (α- and β-muricholic acids), was of the same magnitude in the two groups of animals. Also the daily production of cholic acid was decreased in phenobarbital treated rats compared to control rats (2.12±0.46 mg and 7.24±1.66 mg, respectively). No significant difference was observed between the synthesis of chenodeoxycholic acid in the two groups of animals.

Original languageEnglish (US)
Pages (from-to)844-849
Number of pages6
JournalLipids
Volume9
Issue number11
DOIs
StatePublished - Nov 1 1974

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Cell Biology

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