Changes in in vivo metabolism of bile acids in rat after treatment with phenobarbital

Tomas Cronholm; Kurt Einarsson; Jan Åke Gustafsson

doi:10.1007/BF02532607

Changes in in vivo metabolism of bile acids in rat after treatment with phenobarbital

Tomas Cronholm, Kurt Einarsson, Jan Åke Gustafsson

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Abstract

The influence of phenobarbital on pool size and turnover of bile acids in rats have been investigated by administration of [24-¹⁴C] cholic acid and tritium labeled chenodeoxycholic acid. Phenobarbital treated rats had a smaller cholic acid pool compared to control rats (6.08±2.09 mg and 23.60±7.66 mg, respectively). The pool size of chenodeoxycholic acid, plus its metabolites (α- and β-muricholic acids), was of the same magnitude in the two groups of animals. Also the daily production of cholic acid was decreased in phenobarbital treated rats compared to control rats (2.12±0.46 mg and 7.24±1.66 mg, respectively). No significant difference was observed between the synthesis of chenodeoxycholic acid in the two groups of animals.

Original language	English (US)
Pages (from-to)	844-849
Number of pages	6
Journal	Lipids
Volume	9
Issue number	11
DOIs	https://doi.org/10.1007/BF02532607
State	Published - Nov 1974

ASJC Scopus subject areas

Biochemistry
Organic Chemistry
Cell Biology

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title = "Changes in in vivo metabolism of bile acids in rat after treatment with phenobarbital",

abstract = "The influence of phenobarbital on pool size and turnover of bile acids in rats have been investigated by administration of [24-14C] cholic acid and tritium labeled chenodeoxycholic acid. Phenobarbital treated rats had a smaller cholic acid pool compared to control rats (6.08±2.09 mg and 23.60±7.66 mg, respectively). The pool size of chenodeoxycholic acid, plus its metabolites (α- and β-muricholic acids), was of the same magnitude in the two groups of animals. Also the daily production of cholic acid was decreased in phenobarbital treated rats compared to control rats (2.12±0.46 mg and 7.24±1.66 mg, respectively). No significant difference was observed between the synthesis of chenodeoxycholic acid in the two groups of animals.",

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AU - Cronholm, Tomas

AU - Einarsson, Kurt

AU - Gustafsson, Jan Åke

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N2 - The influence of phenobarbital on pool size and turnover of bile acids in rats have been investigated by administration of [24-14C] cholic acid and tritium labeled chenodeoxycholic acid. Phenobarbital treated rats had a smaller cholic acid pool compared to control rats (6.08±2.09 mg and 23.60±7.66 mg, respectively). The pool size of chenodeoxycholic acid, plus its metabolites (α- and β-muricholic acids), was of the same magnitude in the two groups of animals. Also the daily production of cholic acid was decreased in phenobarbital treated rats compared to control rats (2.12±0.46 mg and 7.24±1.66 mg, respectively). No significant difference was observed between the synthesis of chenodeoxycholic acid in the two groups of animals.

AB - The influence of phenobarbital on pool size and turnover of bile acids in rats have been investigated by administration of [24-14C] cholic acid and tritium labeled chenodeoxycholic acid. Phenobarbital treated rats had a smaller cholic acid pool compared to control rats (6.08±2.09 mg and 23.60±7.66 mg, respectively). The pool size of chenodeoxycholic acid, plus its metabolites (α- and β-muricholic acids), was of the same magnitude in the two groups of animals. Also the daily production of cholic acid was decreased in phenobarbital treated rats compared to control rats (2.12±0.46 mg and 7.24±1.66 mg, respectively). No significant difference was observed between the synthesis of chenodeoxycholic acid in the two groups of animals.

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Changes in in vivo metabolism of bile acids in rat after treatment with phenobarbital

Abstract

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