Changes in coronary plaque volume: Comparison of serial measurements on intravascular ultrasound and coronary computed tomographic angiography

Rine Nakanishi, Anas Alani, Suguru Matsumoto, Dong Li, Michael Fahmy, Jeby Abraham, Christopher Dailing, Alexander Broersen, Pieter H. Kitslaar, Khurram Nasir, James K. Min, Matthew J. Budoff

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Serial measurements of coronary plaque volume have been used to evaluate drug efficacy in atherosclerotic progression. However, the usefulness of computed tomography for this purpose is unknown. We investigated whether the change in total plaque volume on coronary computed tomographic angiography is associated with the change in segment plaque volume on intravascular ultrasound. We prospectively enrolled 11 consecutive patients (mean age, 56.3 ± 5 yr; 6 men) who were to undergo serial invasive coronary angiographic examinations with use of grayscale intravascular ultrasound and coronary computed tomography, performed <180 days apart at baseline and from 1 to 2 years later. Subjects underwent 186 serial measurements of total plaque volume on coronary computed tomography and 22 of segmental plaque volume on intravascular ultrasound. We used semiautomated software to examine percentage relationships and changes between total plaque and segmental plaque volumes. No significant correlations were found between percentages of total coronary and segment coronary plaque volume, nor between normalized coronary plaque volume. However, in the per-patient analysis, there were strong correlations between the imaging methods for changes in total coronary and segment coronary plaque volume (r=0.62; P=0.04), as well as normalized plaque volume (r=0.82; P=0.002). Per-patient change in plaque volume on coronary computed tomography is significantly associated with that on intravascular ultrasound. Computed tomographic angiography may be safer and more widely available than intravascular ultrasound for evaluating atherosclerotic progression in coronary arteries. Larger studies are warranted.

Original languageEnglish (US)
Pages (from-to)84-91
Number of pages8
JournalTexas Heart Institute Journal
Volume45
Issue number2
DOIs
StatePublished - Apr 2018

Keywords

  • Coronary angiography/methods
  • Coronary vessels/diagnostic imaging
  • Disease progression
  • Image interpretation, computer-assisted
  • Plaque, atherosclerotic/diagnostic imaging
  • Predictive value of tests
  • Prospective studies
  • Time factors
  • Tomography, x-ray computed/methods
  • Ultrasonography, interventional/ methods

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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