Changes in body composition over 8 years in a randomized trial of a lifestyle intervention: The look AHEAD study

Research output: Contribution to journalArticle

Henry J. Pownall, George A. Bray, Lynne E. Wagenknecht, Michael P. Walkup, Stanley Heshka, Van S. Hubbard, James Hill, Steven E. Kahn, David M. Nathan, Anne V. Schwartz, Karen C. Johnson

Objective To determine the effects of an intensive lifestyle intervention versus a comparison group on body composition in obese or overweight persons with type 2 diabetes at baseline and at 1, 4, and 8 years. Methods Body composition was measured by dual-energy X-ray absorptiometry in a subset of 1019 Look AHEAD study volunteers randomized to intervention or comparison groups. The intervention was designed to achieve and maintain ≥7% weight loss through increased physical activity and reduced caloric intake. The comparison group received social support and diabetes education. Results At 1 year, the intervention group lost fat (5.6 ± 0.2 kg) and lean mass (2.3 ± 0.1 kg) but regained fat (∼100%) and lost lean mass between years 1 and 8. Between baseline and year 8, weight loss was greater in intervention versus comparison groups (4.0 ± 0.4 vs. 2.3 ± 0.4 kg); comparison group weight loss was mostly lean mass (2.1 ± 0.17 kg). Fat mass in the intervention group was lower than that of the comparison group at all post-baseline time points. Conclusions Reduced fat mass may place the intervention group at a lower risk of obesity-linked sequelae, a hypothesis that can be tested by future studies of this cohort.

Original languageEnglish (US)
Pages (from-to)565-572
Number of pages8
JournalObesity
Volume23
Issue number3
DOIs
StatePublished - Mar 1 2015

PMID: 25707379

PMCID: PMC4707962

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Changes in body composition over 8 years in a randomized trial of a lifestyle intervention : The look AHEAD study. / Pownall, Henry J.; Bray, George A.; Wagenknecht, Lynne E.; Walkup, Michael P.; Heshka, Stanley; Hubbard, Van S.; Hill, James; Kahn, Steven E.; Nathan, David M.; Schwartz, Anne V.; Johnson, Karen C.

In: Obesity, Vol. 23, No. 3, 01.03.2015, p. 565-572.

Research output: Contribution to journalArticle

Harvard

Pownall, HJ, Bray, GA, Wagenknecht, LE, Walkup, MP, Heshka, S, Hubbard, VS, Hill, J, Kahn, SE, Nathan, DM, Schwartz, AV & Johnson, KC 2015, 'Changes in body composition over 8 years in a randomized trial of a lifestyle intervention: The look AHEAD study' Obesity, vol. 23, no. 3, pp. 565-572. https://doi.org/10.1002/oby.21005

APA

Pownall, H. J., Bray, G. A., Wagenknecht, L. E., Walkup, M. P., Heshka, S., Hubbard, V. S., ... Johnson, K. C. (2015). Changes in body composition over 8 years in a randomized trial of a lifestyle intervention: The look AHEAD study. Obesity, 23(3), 565-572. https://doi.org/10.1002/oby.21005

Vancouver

Pownall HJ, Bray GA, Wagenknecht LE, Walkup MP, Heshka S, Hubbard VS et al. Changes in body composition over 8 years in a randomized trial of a lifestyle intervention: The look AHEAD study. Obesity. 2015 Mar 1;23(3):565-572. https://doi.org/10.1002/oby.21005

Author

Pownall, Henry J. ; Bray, George A. ; Wagenknecht, Lynne E. ; Walkup, Michael P. ; Heshka, Stanley ; Hubbard, Van S. ; Hill, James ; Kahn, Steven E. ; Nathan, David M. ; Schwartz, Anne V. ; Johnson, Karen C. / Changes in body composition over 8 years in a randomized trial of a lifestyle intervention : The look AHEAD study. In: Obesity. 2015 ; Vol. 23, No. 3. pp. 565-572.

BibTeX

@article{cd9c1166357546e2ab4efc25858c6927,
title = "Changes in body composition over 8 years in a randomized trial of a lifestyle intervention: The look AHEAD study",
abstract = "Objective To determine the effects of an intensive lifestyle intervention versus a comparison group on body composition in obese or overweight persons with type 2 diabetes at baseline and at 1, 4, and 8 years. Methods Body composition was measured by dual-energy X-ray absorptiometry in a subset of 1019 Look AHEAD study volunteers randomized to intervention or comparison groups. The intervention was designed to achieve and maintain ≥7{\%} weight loss through increased physical activity and reduced caloric intake. The comparison group received social support and diabetes education. Results At 1 year, the intervention group lost fat (5.6 ± 0.2 kg) and lean mass (2.3 ± 0.1 kg) but regained fat (∼100{\%}) and lost lean mass between years 1 and 8. Between baseline and year 8, weight loss was greater in intervention versus comparison groups (4.0 ± 0.4 vs. 2.3 ± 0.4 kg); comparison group weight loss was mostly lean mass (2.1 ± 0.17 kg). Fat mass in the intervention group was lower than that of the comparison group at all post-baseline time points. Conclusions Reduced fat mass may place the intervention group at a lower risk of obesity-linked sequelae, a hypothesis that can be tested by future studies of this cohort.",
author = "Pownall, {Henry J.} and Bray, {George A.} and Wagenknecht, {Lynne E.} and Walkup, {Michael P.} and Stanley Heshka and Hubbard, {Van S.} and James Hill and Kahn, {Steven E.} and Nathan, {David M.} and Schwartz, {Anne V.} and Johnson, {Karen C.}",
year = "2015",
month = "3",
day = "1",
doi = "10.1002/oby.21005",
language = "English (US)",
volume = "23",
pages = "565--572",
journal = "Obesity",
issn = "1930-7381",
publisher = "Wiley",
number = "3",

}

RIS

TY - JOUR

T1 - Changes in body composition over 8 years in a randomized trial of a lifestyle intervention

T2 - Obesity

AU - Pownall, Henry J.

AU - Bray, George A.

AU - Wagenknecht, Lynne E.

AU - Walkup, Michael P.

AU - Heshka, Stanley

AU - Hubbard, Van S.

AU - Hill, James

AU - Kahn, Steven E.

AU - Nathan, David M.

AU - Schwartz, Anne V.

AU - Johnson, Karen C.

PY - 2015/3/1

Y1 - 2015/3/1

N2 - Objective To determine the effects of an intensive lifestyle intervention versus a comparison group on body composition in obese or overweight persons with type 2 diabetes at baseline and at 1, 4, and 8 years. Methods Body composition was measured by dual-energy X-ray absorptiometry in a subset of 1019 Look AHEAD study volunteers randomized to intervention or comparison groups. The intervention was designed to achieve and maintain ≥7% weight loss through increased physical activity and reduced caloric intake. The comparison group received social support and diabetes education. Results At 1 year, the intervention group lost fat (5.6 ± 0.2 kg) and lean mass (2.3 ± 0.1 kg) but regained fat (∼100%) and lost lean mass between years 1 and 8. Between baseline and year 8, weight loss was greater in intervention versus comparison groups (4.0 ± 0.4 vs. 2.3 ± 0.4 kg); comparison group weight loss was mostly lean mass (2.1 ± 0.17 kg). Fat mass in the intervention group was lower than that of the comparison group at all post-baseline time points. Conclusions Reduced fat mass may place the intervention group at a lower risk of obesity-linked sequelae, a hypothesis that can be tested by future studies of this cohort.

AB - Objective To determine the effects of an intensive lifestyle intervention versus a comparison group on body composition in obese or overweight persons with type 2 diabetes at baseline and at 1, 4, and 8 years. Methods Body composition was measured by dual-energy X-ray absorptiometry in a subset of 1019 Look AHEAD study volunteers randomized to intervention or comparison groups. The intervention was designed to achieve and maintain ≥7% weight loss through increased physical activity and reduced caloric intake. The comparison group received social support and diabetes education. Results At 1 year, the intervention group lost fat (5.6 ± 0.2 kg) and lean mass (2.3 ± 0.1 kg) but regained fat (∼100%) and lost lean mass between years 1 and 8. Between baseline and year 8, weight loss was greater in intervention versus comparison groups (4.0 ± 0.4 vs. 2.3 ± 0.4 kg); comparison group weight loss was mostly lean mass (2.1 ± 0.17 kg). Fat mass in the intervention group was lower than that of the comparison group at all post-baseline time points. Conclusions Reduced fat mass may place the intervention group at a lower risk of obesity-linked sequelae, a hypothesis that can be tested by future studies of this cohort.

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U2 - 10.1002/oby.21005

DO - 10.1002/oby.21005

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VL - 23

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JO - Obesity

JF - Obesity

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