Changes in α7β1 integrin signaling after eccentric exercise in heat-shocked rat soleus

Zachary A. Graham, Chad D. Touchberry, Anisha A. Gupte, Gregory L. Bomhoff, Paige C. Geiger, Philip M. Gallagher

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Introduction: α7β1 integrin links the extracellular matrix to the focal adhesion (FA) in skeletal muscle and serves as a stabilizing and signal relayer. Heat shock (HS) induces expression of proteins that interact with the FA. Methods: Male Wistar rats were assigned to 1 of 3 groups: control (CON); eccentric exercise (EE); or EE+HS (HS). Soleus muscle was analyzed at 2 h and 48 h post-exercise. Results: The 120-kDa α7 integrin decreased in the EE and HS groups, and the 70-kDa peptide decreased in the EE group at 2 h post-exercise. Total expression of focal adhesion kinase (FAK) and RhoA were decreased in EE and HS at 2 h post-exercise. Expression of phosphorylated FAK397 decreased in the EE group but not the HS group at 2 h post-exercise. Conclusions: Long-duration EE may cause alterations in the FA in rat soleus muscle through the α7 integrin subunit and FAK.

Original languageEnglish (US)
Pages (from-to)562-568
Number of pages7
JournalMuscle and Nerve
Volume51
Issue number4
DOIs
StatePublished - Apr 1 2015

Keywords

  • Costamere
  • Eccentric exercise
  • FAK
  • Heat shock
  • Integrin

ASJC Scopus subject areas

  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)
  • Physiology
  • Medicine(all)

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