Challenges in the evaluation and management of bone and joint infections and the role of new antibiotics for Gram positive infections

Sheldon L. Kaplan

doi:10.1007/978-0-387-79838-7_10

Challenges in the evaluation and management of bone and joint infections and the role of new antibiotics for Gram positive infections

Sheldon L. Kaplan

Houston Methodist

Research output: Chapter in Book/Report/Conference proceeding › Chapter

10 Scopus citations

Abstract

CA-MRSA isolates are increasingly common pathogens in children with acute, hematogenously acquired osteomyelitis and clinicians have to consider this pathogen in the selection of initial empiric treatment. With the emergence of pvl+ CA-MRSA isolates, unusual manifestations of acute osteomyelitis have become common including venous thromboses and multiple sites of infection. MRI is currently the imaging modality of choice for osteomyelitis. Drainage of purulent collections is also more common in association with the pvl+ strains. The role of newer antibiotics such as linezolid and daptomycin for the treatment of CA-MRSA musculoskeletal infections in children needs further study.

Original language	English (US)
Title of host publication	Advances in Experimental Medicine and Biology
Publisher	Springer New York
Pages	111-120
Number of pages	10
Volume	634
ISBN (Print)	9780387798370
DOIs	https://doi.org/10.1007/978-0-387-79838-7_10
State	Published - 2009

Publication series

Name	Advances in Experimental Medicine and Biology
Volume	634
ISSN (Print)	00652598

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology
General Medicine

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10.1007/978-0-387-79838-7_10

Cite this

Challenges in the evaluation and management of bone and joint infections and the role of new antibiotics for Gram positive infections. / Kaplan, Sheldon L.
Advances in Experimental Medicine and Biology. Vol. 634 Springer New York, 2009. p. 111-120 (Advances in Experimental Medicine and Biology; Vol. 634).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

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AB - CA-MRSA isolates are increasingly common pathogens in children with acute, hematogenously acquired osteomyelitis and clinicians have to consider this pathogen in the selection of initial empiric treatment. With the emergence of pvl+ CA-MRSA isolates, unusual manifestations of acute osteomyelitis have become common including venous thromboses and multiple sites of infection. MRI is currently the imaging modality of choice for osteomyelitis. Drainage of purulent collections is also more common in association with the pvl+ strains. The role of newer antibiotics such as linezolid and daptomycin for the treatment of CA-MRSA musculoskeletal infections in children needs further study.

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Challenges in the evaluation and management of bone and joint infections and the role of new antibiotics for Gram positive infections

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