Challenges in the evaluation and management of bone and joint infections and the role of new antibiotics for Gram positive infections

Sheldon L. Kaplan

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

CA-MRSA isolates are increasingly common pathogens in children with acute, hematogenously acquired osteomyelitis and clinicians have to consider this pathogen in the selection of initial empiric treatment. With the emergence of pvl+ CA-MRSA isolates, unusual manifestations of acute osteomyelitis have become common including venous thromboses and multiple sites of infection. MRI is currently the imaging modality of choice for osteomyelitis. Drainage of purulent collections is also more common in association with the pvl+ strains. The role of newer antibiotics such as linezolid and daptomycin for the treatment of CA-MRSA musculoskeletal infections in children needs further study.

Original languageEnglish
Title of host publicationAdvances in Experimental Medicine and Biology
Pages111-120
Number of pages10
Volume634
DOIs
StatePublished - Dec 1 2009

Publication series

NameAdvances in Experimental Medicine and Biology
Volume634
ISSN (Print)00652598

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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