TY - CHAP
T1 - Challenges in the evaluation and management of bone and joint infections and the role of new antibiotics for Gram positive infections
AU - Kaplan, Sheldon L.
PY - 2009/12/1
Y1 - 2009/12/1
N2 - CA-MRSA isolates are increasingly common pathogens in children with acute, hematogenously acquired osteomyelitis and clinicians have to consider this pathogen in the selection of initial empiric treatment. With the emergence of pvl+ CA-MRSA isolates, unusual manifestations of acute osteomyelitis have become common including venous thromboses and multiple sites of infection. MRI is currently the imaging modality of choice for osteomyelitis. Drainage of purulent collections is also more common in association with the pvl+ strains. The role of newer antibiotics such as linezolid and daptomycin for the treatment of CA-MRSA musculoskeletal infections in children needs further study.
AB - CA-MRSA isolates are increasingly common pathogens in children with acute, hematogenously acquired osteomyelitis and clinicians have to consider this pathogen in the selection of initial empiric treatment. With the emergence of pvl+ CA-MRSA isolates, unusual manifestations of acute osteomyelitis have become common including venous thromboses and multiple sites of infection. MRI is currently the imaging modality of choice for osteomyelitis. Drainage of purulent collections is also more common in association with the pvl+ strains. The role of newer antibiotics such as linezolid and daptomycin for the treatment of CA-MRSA musculoskeletal infections in children needs further study.
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U2 - 10.1007/978-0-387-79838-7-10
DO - 10.1007/978-0-387-79838-7-10
M3 - Chapter
C2 - 19280853
SN - 9780387798370
VL - 634
T3 - Advances in Experimental Medicine and Biology
SP - 111
EP - 120
BT - Advances in Experimental Medicine and Biology
ER -