Abstract
Economic evaluation in the form of cost-effectiveness analysis has become a popular means to inform decisions in healthcare. With multi-regional clinical trials in a global development program becoming a new venue for drug efficacy testing in recent decades, questions in methods for cost-effectiveness analysis in the multi-regional clinical trials setting also emerge. This paper addresses some challenges from variation across regions in cost effectiveness analysis in multi-regional clinical trials. Several discussion points are raised for further attention and a multi-regional clinical trial example is presented to illustrate the implications in industrial application. A general message is delivered to call for a depth discussion by all stakeholders to reach an agreement on a good practice in cost-effectiveness analysis in the multi-regional clinical trials. Meanwhile, we recommend an additional consideration of cost-effectiveness analysis results based on the clinical evidence from a certain homogeneous population as sensitivity or scenario analysis upon data availability.
| Original language | English (US) |
|---|---|
| Article number | 371 |
| Journal | Frontiers in Pharmacology |
| Volume | 7 |
| Issue number | OCT |
| DOIs | |
| State | Published - Oct 28 2016 |
Keywords
- Clinical evidence
- Cost-effectiveness analysis
- Ethnic factors
- Multi-regional clinical trials
- Sensitivity analysis
ASJC Scopus subject areas
- Pharmacology
- Pharmacology (medical)