Challenges enrolling patients with acute ischemic stroke into cell therapy trials

Farhaan S. Vahidy, Susan Alderman, Sean I. Savitz

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Infusion of autologous bone marrow-derived mononuclear cells (MNCs) is a promising investigational therapeutic approach for patients with acute ischemic stroke. Preclinical models indicate that MNCs can reduce neurological deficits and enhance recovery. We recently concluded a phase I clinical trial to determine the safety and feasibility of these cells in patients with acute ischemic stroke. In this article, we discuss practical barriers and challenges encountered during the trial and provide lessons learned for the design and planning of future clinical trials testing novel cell therapies for acute ischemic stroke.

Original languageEnglish (US)
Pages (from-to)27-30
Number of pages4
JournalStem Cells and Development
Volume22
Issue number1
DOIs
StatePublished - Jan 1 2013

ASJC Scopus subject areas

  • Hematology
  • Developmental Biology
  • Cell Biology

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