TY - JOUR
T1 - Cervical transcutaneous spinal stimulation for spinal motor mapping
AU - Oh, Jeonghoon
AU - Steele, Alexander G.
AU - Varghese, Blesson
AU - Martin, Catherine A.
AU - Scheffler, Michelle S.
AU - Markley, Rachel L.
AU - Lo, Yi Kai
AU - Sayenko, Dimitry G.
N1 - Publisher Copyright:
© 2022
PY - 2022/10/21
Y1 - 2022/10/21
N2 - Transcutaneous spinal stimulation (TSS) is a promising approach to restore upper-limb (UL) functions after spinal cord injury (SCI) in humans. We sought to demonstrate the selectivity of recruitment of individual UL motor pools during cervical TSS using different electrode placements. We demonstrated that TSS delivered over the rostrocaudal and mediolateral axes of the cervical spine resulted in a preferential activation of proximal, distal, and ipsilateral UL muscles. This was revealed by changes in motor threshold intensity, maximum amplitude, and the amount of post-activation depression of the evoked responses. We propose that an arrangement of electrodes targeting specific UL motor pools may result in superior efficacy, restoring more diverse motor activities after neurological injuries and disorders, including severe SCI.
AB - Transcutaneous spinal stimulation (TSS) is a promising approach to restore upper-limb (UL) functions after spinal cord injury (SCI) in humans. We sought to demonstrate the selectivity of recruitment of individual UL motor pools during cervical TSS using different electrode placements. We demonstrated that TSS delivered over the rostrocaudal and mediolateral axes of the cervical spine resulted in a preferential activation of proximal, distal, and ipsilateral UL muscles. This was revealed by changes in motor threshold intensity, maximum amplitude, and the amount of post-activation depression of the evoked responses. We propose that an arrangement of electrodes targeting specific UL motor pools may result in superior efficacy, restoring more diverse motor activities after neurological injuries and disorders, including severe SCI.
KW - Biological sciences
KW - Clinical neuroscience
KW - Neuroscience
KW - Techniques in neuroscience
UR - http://www.scopus.com/inward/record.url?scp=85138016976&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85138016976&partnerID=8YFLogxK
U2 - 10.1016/j.isci.2022.105037
DO - 10.1016/j.isci.2022.105037
M3 - Article
C2 - 36147963
AN - SCOPUS:85138016976
SN - 2589-0042
VL - 25
SP - 105037
JO - iScience
JF - iScience
IS - 10
M1 - 105037
ER -