Cerebromicrocirculatory defects in animal model of depression

Sheldon H. Preskorn; Thomas A. Kent; Robin K. Glotzbach; George H. Irwin; Jay V. Solnick

doi:10.1007/BF00427445

Cerebromicrocirculatory defects in animal model of depression

Sheldon H. Preskorn, Thomas A. Kent, Robin K. Glotzbach, George H. Irwin, Jay V. Solnick

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13 Scopus citations

Abstract

In the tetrabenazine (TBZ) model of depression, the cerebromicrocirculation was discovered to respond abnormally to metabolic demand as mimicked by the administration of CO₂. Altered responsivity of cerebral blood flow and effective permeability of the blood - brain barrier to changes in PaCO₂ were found. These physiologic defects coincided temporally with TBZ-induced depletion of central norepinephrine and dopamine and with the development of the behavioral effects of TBZ (the end points used to test the antidepressant potential of experimental drugs). Pretreatment with amitriptyline (a standard antidepressant and amine reuptake inhibitor) prevented the development of these TBZ-induced abnormalities in the cerebromicrocirculation, just as it prevented the behavioral effects.

Original language	English (US)
Pages (from-to)	196-199
Number of pages	4
Journal	Psychopharmacology
Volume	84
Issue number	2
DOIs	https://doi.org/10.1007/BF00427445
State	Published - Oct 1 1984

Keywords

Animal model
Biogenic amines
Bood-brain barrier
Cerebral blood flow
Depression
Tetrabenazine

ASJC Scopus subject areas

Pharmacology

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10.1007/BF00427445

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title = "Cerebromicrocirculatory defects in animal model of depression",

abstract = "In the tetrabenazine (TBZ) model of depression, the cerebromicrocirculation was discovered to respond abnormally to metabolic demand as mimicked by the administration of CO2. Altered responsivity of cerebral blood flow and effective permeability of the blood - brain barrier to changes in PaCO2 were found. These physiologic defects coincided temporally with TBZ-induced depletion of central norepinephrine and dopamine and with the development of the behavioral effects of TBZ (the end points used to test the antidepressant potential of experimental drugs). Pretreatment with amitriptyline (a standard antidepressant and amine reuptake inhibitor) prevented the development of these TBZ-induced abnormalities in the cerebromicrocirculation, just as it prevented the behavioral effects.",

keywords = "Animal model, Biogenic amines, Bood-brain barrier, Cerebral blood flow, Depression, Tetrabenazine",

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T1 - Cerebromicrocirculatory defects in animal model of depression

AU - Preskorn, Sheldon H.

AU - Kent, Thomas A.

AU - Glotzbach, Robin K.

AU - Irwin, George H.

AU - Solnick, Jay V.

PY - 1984/10/1

Y1 - 1984/10/1

N2 - In the tetrabenazine (TBZ) model of depression, the cerebromicrocirculation was discovered to respond abnormally to metabolic demand as mimicked by the administration of CO2. Altered responsivity of cerebral blood flow and effective permeability of the blood - brain barrier to changes in PaCO2 were found. These physiologic defects coincided temporally with TBZ-induced depletion of central norepinephrine and dopamine and with the development of the behavioral effects of TBZ (the end points used to test the antidepressant potential of experimental drugs). Pretreatment with amitriptyline (a standard antidepressant and amine reuptake inhibitor) prevented the development of these TBZ-induced abnormalities in the cerebromicrocirculation, just as it prevented the behavioral effects.

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KW - Cerebral blood flow

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Cerebromicrocirculatory defects in animal model of depression

Abstract

Keywords

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