Cerebral cortical neurons with activity linked to central neurogenic spontaneous and evoked elevations in cerebral blood flow

Eugene V. Golanov, Donald J. Reis

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

We recorded neurons in rat cerebral cortex with activity relating to the neurogenic elevations in regional cerebral blood flow (rCBF) coupled to stereotyped bursts of EEG activity, burst-cerebrovascular wave complexes, appearing spontaneously or evoked by electrical stimulation of rostral ventrolateral medulla (RVL) or fastigial nucleus (FN). Of 333 spontaneously active neurons only 15 (5%), in layers 5-6, consistently (P < 0.05, chi-square) increased their activity during the earliest potential of the complex, ~1.3 s before the rise of rCBF, and during the minutes-long elevation of rCBF elicited by 10 s of stimulation of RVL or FN. The results indicate the presence of a small population of neurons in deep cortical laminae whose activity correlates with neurogenic elevations of rCBF. These neurons may function to transduce afferent neuronal signals into vasodilation.

Original languageEnglish (US)
Pages (from-to)101-104
Number of pages4
JournalNeuroscience Letters
Volume209
Issue number2
DOIs
StatePublished - May 10 1996

Keywords

  • Cerebral cortex
  • EEG
  • Electrical stimulation
  • Fastigial nucleus
  • Neurons
  • Regional cerebral blood flow
  • Rostral ventrolateral medulla
  • Vasodilation

ASJC Scopus subject areas

  • Neuroscience(all)

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