Cerebral blood volume in a rat model of ischemia by MR imaging at 4.7 T

T. A. Kent; M. J. Quast; B. J. Kaplan; A. Najafi; E. G. Amparo; R. M. Gevedon; F. Salinas; A. D. Suttle; D. J. DiPette; H. M. Eisenberg

Cerebral blood volume in a rat model of ischemia by MR imaging at 4.7 T

T. A. Kent, M. J. Quast, B. J. Kaplan, A. Najafi, E. G. Amparo, R. M. Gevedon, F. Salinas, A. D. Suttle, D. J. DiPette, H. M. Eisenberg

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

Perturbation of the cerebral circulation by occlusion of the vertebral arteries and a carotid artery can be visualized by using MR imaging and the intravascular contrast agent Gd-DTPA complexed to albumin. This tracer consistently reduced the T1 relaxation time in the brain and blood. The difference between hemispheres was revealed by less T1 reduction in the occluded hemisphere and by an adjustment in the display contrast of images that revealed the territory of decreased perfusion. These results were confirmed by comparing them with cerebral blood flow using radioactive microspheres and the intravascular blood volume tracer ⁵¹Cr-EDTA. This method, combined with high-resolution MR imaging, can be applied to serial noninvasive studies of cerebral blood volume in ischemia and other conditions.

Original language	English (US)
Pages (from-to)	335-338
Number of pages	4
Journal	American Journal of Neuroradiology
Volume	10
Issue number	2
State	Published - 1989

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging
Clinical Neurology

Cite this

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title = "Cerebral blood volume in a rat model of ischemia by MR imaging at 4.7 T",

abstract = "Perturbation of the cerebral circulation by occlusion of the vertebral arteries and a carotid artery can be visualized by using MR imaging and the intravascular contrast agent Gd-DTPA complexed to albumin. This tracer consistently reduced the T1 relaxation time in the brain and blood. The difference between hemispheres was revealed by less T1 reduction in the occluded hemisphere and by an adjustment in the display contrast of images that revealed the territory of decreased perfusion. These results were confirmed by comparing them with cerebral blood flow using radioactive microspheres and the intravascular blood volume tracer 51Cr-EDTA. This method, combined with high-resolution MR imaging, can be applied to serial noninvasive studies of cerebral blood volume in ischemia and other conditions.",

author = "Kent, {T. A.} and Quast, {M. J.} and Kaplan, {B. J.} and A. Najafi and Amparo, {E. G.} and Gevedon, {R. M.} and F. Salinas and Suttle, {A. D.} and DiPette, {D. J.} and Eisenberg, {H. M.}",

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AU - Kent, T. A.

AU - Quast, M. J.

AU - Kaplan, B. J.

AU - Najafi, A.

AU - Amparo, E. G.

AU - Gevedon, R. M.

AU - Salinas, F.

AU - Suttle, A. D.

AU - DiPette, D. J.

AU - Eisenberg, H. M.

PY - 1989

Y1 - 1989

N2 - Perturbation of the cerebral circulation by occlusion of the vertebral arteries and a carotid artery can be visualized by using MR imaging and the intravascular contrast agent Gd-DTPA complexed to albumin. This tracer consistently reduced the T1 relaxation time in the brain and blood. The difference between hemispheres was revealed by less T1 reduction in the occluded hemisphere and by an adjustment in the display contrast of images that revealed the territory of decreased perfusion. These results were confirmed by comparing them with cerebral blood flow using radioactive microspheres and the intravascular blood volume tracer 51Cr-EDTA. This method, combined with high-resolution MR imaging, can be applied to serial noninvasive studies of cerebral blood volume in ischemia and other conditions.

AB - Perturbation of the cerebral circulation by occlusion of the vertebral arteries and a carotid artery can be visualized by using MR imaging and the intravascular contrast agent Gd-DTPA complexed to albumin. This tracer consistently reduced the T1 relaxation time in the brain and blood. The difference between hemispheres was revealed by less T1 reduction in the occluded hemisphere and by an adjustment in the display contrast of images that revealed the territory of decreased perfusion. These results were confirmed by comparing them with cerebral blood flow using radioactive microspheres and the intravascular blood volume tracer 51Cr-EDTA. This method, combined with high-resolution MR imaging, can be applied to serial noninvasive studies of cerebral blood volume in ischemia and other conditions.

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Cerebral blood volume in a rat model of ischemia by MR imaging at 4.7 T

Abstract

ASJC Scopus subject areas

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