TY - JOUR
T1 - Cerebral blood flow and cerebrovascular permeability in an inescapable shock (learned helplessness) animal model of depression
AU - Hughes, Carroll W.
AU - Kent, Thomas A.
AU - Campbell, Jan
AU - Oke, Arvin
AU - Croskell, Heather
AU - Preskorn, Sheldon H.
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 1984
Y1 - 1984
N2 - The effects of a purported animal model of depression (inescapable shock, IS) was tested on: (a) escape behavior, (b) regional brain levels of norepinephrine (NE), serotonin (5-HT), and dopamine, and (c), the response of the cerebromicrovasculature to metabolic demand as mimicked by manipulation of arterial CO2 content (PaCO2). Multidisciplinary research has implicated central biogenic amines in the regulation of cerebromicrocirculation. IS treatment resulted in increased escape latency and lowered levels of NE and 5-HT in the locus coeruleus but not in terminal fields in distant regions. This treatment also did not alter cerebral blood flow or capillary permeability in distant regions when compared with control rats. Thus, the discrete changes in NE and 5-HT in locus coeruleus induced by IS treatment is not reflected in changes in cerebral blood flow and the effective permeability of the blood-brain barrier.
AB - The effects of a purported animal model of depression (inescapable shock, IS) was tested on: (a) escape behavior, (b) regional brain levels of norepinephrine (NE), serotonin (5-HT), and dopamine, and (c), the response of the cerebromicrovasculature to metabolic demand as mimicked by manipulation of arterial CO2 content (PaCO2). Multidisciplinary research has implicated central biogenic amines in the regulation of cerebromicrocirculation. IS treatment resulted in increased escape latency and lowered levels of NE and 5-HT in the locus coeruleus but not in terminal fields in distant regions. This treatment also did not alter cerebral blood flow or capillary permeability in distant regions when compared with control rats. Thus, the discrete changes in NE and 5-HT in locus coeruleus induced by IS treatment is not reflected in changes in cerebral blood flow and the effective permeability of the blood-brain barrier.
KW - Animal model depression
KW - Cerebral blood flow
KW - Cerebrovascular permeability
KW - Learned helplessness
KW - Locus coeruleus
KW - Monoamines
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U2 - 10.1016/S0091-3057(84)80070-2
DO - 10.1016/S0091-3057(84)80070-2
M3 - Article
C2 - 6441169
AN - SCOPUS:0021674978
VL - 21
SP - 891
EP - 894
JO - Pharmacology Biochemistry and Behavior
JF - Pharmacology Biochemistry and Behavior
SN - 0091-3057
IS - 6
ER -