Cerebral benzodiazepine receptors in depressed patients measured with [123I]iomazenil SPECT

Akira Kugaya, Gerard Sanacora, Nicolaas P.L.G. Verhoeff, Masahiro Fujita, Graeme F. Mason, Nicholas M. Seneca, Ali Bozkurt, Shaukat A. Khan, Amit Anand, Kathleen Degen, Dennis S. Charney, Sami S. Zoghbi, Ronald M. Baldwin, John P. Seibyl, Robert B. Innis

Research output: Contribution to journalArticle

47 Scopus citations

Abstract

Background: A recent magnetic resonance spectroscopy (MRS) study revealed low γ-aminobutyric acid (GABA) levels in the occipital cortex of depressed patients. No in vivo study has been reported to measure postsynaptic GABA receptors in the patients. Methods: Cortical benzodiazepine (BZ) binding to GABAA receptors was measured with [123I]iomazenil and single photon emission computed tomography in unmedicated patients with unipolar major depression (n = 13) and healthy subjects (n = 19). Group differences were evaluated by means of statistical parametric mapping (SPM) with partial volume correction for gray matter. Occipital GABA levels were determined by proton MRS in a subgroup (n = 6) of the patients. Results: No evidence of altered BZ binding was found in patients with depression compared with healthy control subjects in the SPM analysis. Although reduction in gray matter volume was observed in the frontal cortex and amygdala of the patients, partial volume correction of the atrophy did not change the result of unaltered BZ binding. GABA levels were found lower in the occipital cortex; however, BZ binding did not show significant relationship to GABA levels. Conclusions: GABAA receptor binding measured in vivo with BZ radioligand binding are not altered in patients with depression.

Original languageEnglish (US)
Pages (from-to)792-799
Number of pages8
JournalBiological Psychiatry
Volume54
Issue number8
DOIs
StatePublished - Oct 15 2003

Keywords

  • Benzodiazepine receptor
  • GABA
  • Iomazenil
  • MRS
  • Major depression
  • SPECT

ASJC Scopus subject areas

  • Biological Psychiatry

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