Central control of lactogenic receptors in liver membranes: Effect of hypothalamic deafferentation

Gunnar Norstedt, Peter Eneroth, Jan Åke Gustafsson, Tomas Hökfelt, Paul Skett

Research output: Contribution to journalReview article

9 Scopus citations

Abstract

The regulation by the central nervous system of a lactogenic receptor, present in the rat liver, was studied. The receptor, which is present in very low concentration or absent in the male rat, can be induced by anterior hypothalamic deafferentation, resulting in a typically female level of the receptor in lesioned male animals. Our observations indicate an important role of the brain in regulation of peripheral lactogenic receptors.

Original languageEnglish (US)
Pages (from-to)199-204
Number of pages6
JournalMolecular and cellular endocrinology
Volume16
Issue number3
DOIs
StatePublished - Dec 1979

Keywords

  • hypothalamus
  • prolactin receptor
  • sex difference

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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