Central catecholamine neurons and exposure to dichloromethane. Selective changes in amine levels and turnover in tel- and diencephalic DA and NA nerve terminal systems and in the secretion of anterior pituitary hormones in the male rat

K. Fuxe, K. Andersson, T. Hansson, L. F. Agnati, P. Eneroth, J. Å Gustafsson

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Subacute exposure of male rats to various concentrations (70-1000 ppm) of dichloromethane (DCM) produces a selective reduction of dopamine (DA) levels without a change of DA turnover in certain types of forebrain DA nerve terminal systems. In the low concentration (70 ppm) a selective reduction of DA turnover was observed in the medial palisade zone (MPZ) of the median eminence. This chlorinated organic solvent also produced a discrete dose-dependent increase of noradrenaline (NA) turnover within the.

Original languageEnglish (US)
Pages (from-to)293-305
Number of pages13
JournalToxicology
Volume29
Issue number4
DOIs
StatePublished - Feb 1 1984

ASJC Scopus subject areas

  • Toxicology

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