Cellular localization of serotonin transporter mRNA in the rat brain

M. Fujita, S. Shimada, H. Maeno, T. Nishimura, M. Tohyama

Research output: Contribution to journalArticlepeer-review

68 Scopus citations


Expression of serotonin (5-hydroxytryptamine, 5-HT) transporter mRNA in the rat brain was examined by in situ hybridization histochemistry with a synthetic oligonucleotide probe. 5-HT transporter mRNA was expressed in neurons in most of the raphe nuclei. The dorsal and median raphe nuclei contained intensely labeled neurons, while the caudal linear nucleus, raphe magnus nucleus, raphe pontis nucleus, raphe pallidus nucleus and the raphe obscurus nucleus contained weakly or moderately labeled neurons. The localization pattern of the 5-HT transporter mRNA-positive neurons coincides fairly well with that of 5-HT-immunoreactive neurons, indicating that 5-HT transporter is primarily located in serotonergic neurons.

Original languageEnglish (US)
Pages (from-to)59-62
Number of pages4
JournalNeuroscience Letters
Issue number1-2
StatePublished - Nov 12 1993


  • In situ hybridization histochemistry
  • Raphe nucleus
  • Serotonin transporter mRNA

ASJC Scopus subject areas

  • Neuroscience(all)


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