TY - JOUR
T1 - Cellular localization of serotonin transporter mRNA in the rat brain
AU - Fujita, M.
AU - Shimada, S.
AU - Maeno, H.
AU - Nishimura, T.
AU - Tohyama, M.
PY - 1993/11/12
Y1 - 1993/11/12
N2 - Expression of serotonin (5-hydroxytryptamine, 5-HT) transporter mRNA in the rat brain was examined by in situ hybridization histochemistry with a synthetic oligonucleotide probe. 5-HT transporter mRNA was expressed in neurons in most of the raphe nuclei. The dorsal and median raphe nuclei contained intensely labeled neurons, while the caudal linear nucleus, raphe magnus nucleus, raphe pontis nucleus, raphe pallidus nucleus and the raphe obscurus nucleus contained weakly or moderately labeled neurons. The localization pattern of the 5-HT transporter mRNA-positive neurons coincides fairly well with that of 5-HT-immunoreactive neurons, indicating that 5-HT transporter is primarily located in serotonergic neurons.
AB - Expression of serotonin (5-hydroxytryptamine, 5-HT) transporter mRNA in the rat brain was examined by in situ hybridization histochemistry with a synthetic oligonucleotide probe. 5-HT transporter mRNA was expressed in neurons in most of the raphe nuclei. The dorsal and median raphe nuclei contained intensely labeled neurons, while the caudal linear nucleus, raphe magnus nucleus, raphe pontis nucleus, raphe pallidus nucleus and the raphe obscurus nucleus contained weakly or moderately labeled neurons. The localization pattern of the 5-HT transporter mRNA-positive neurons coincides fairly well with that of 5-HT-immunoreactive neurons, indicating that 5-HT transporter is primarily located in serotonergic neurons.
KW - In situ hybridization histochemistry
KW - Raphe nucleus
KW - Serotonin transporter mRNA
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U2 - 10.1016/0304-3940(93)90559-4
DO - 10.1016/0304-3940(93)90559-4
M3 - Article
C2 - 8121638
AN - SCOPUS:0027425434
SN - 0304-3940
VL - 162
SP - 59
EP - 62
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 1-2
ER -