Cellular immunotherapy of cancer.

Fatma V. Okur, Malcolm Brenner

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Standard therapies for many common cancers remain toxic and are often ineffective. Cellular immunotherapy has the potential to be a highly targeted alternative, with low toxicity to normal tissues but a high capacity to eradicate tumor. In this chapter we describe approaches that generate cellular therapies using active immunization with cells, proteins, peptides, or nucleic acids, as well as efforts that use adoptive transfer of effector cells that directly target antigens on malignant cells. Many of these approaches are proving successful in hematologic malignancy and in melanoma. In this chapter we discuss the advantages and limitations of each and how over the next decade investigators will attempt to broaden their reach, increase their efficacy, and simplify their application.

Original languageEnglish (US)
Pages (from-to)319-345
Number of pages27
JournalMethods in molecular biology (Clifton, N.J.)
Volume651
DOIs
StatePublished - Nov 12 2010

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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