Cell encapsulation: Overcoming barriers in cell transplantation in diabetes and beyond

Research output: Contribution to journalReview article

M. Farina, Jenolyn F. Alexander, Usha Thekkedath, Mauro Ferrari, Alessandro Grattoni

Cell-based therapy is emerging as a promising strategy for treating a wide range of human diseases, such as diabetes, blood disorders, acute liver failure, spinal cord injury, and several types of cancer. Pancreatic islets, blood cells, hepatocytes, and stem cells are among the many cell types currently used for this strategy. The encapsulation of these “therapeutic” cells is under intense investigation to not only prevent immune rejection but also provide a controlled and supportive environment so they can function effectively. Some of the advanced encapsulation systems provide active agents to the cells and enable a complete retrieval of the graft in the case of an adverse body reaction. Here, we review various encapsulation strategies developed in academic and industrial settings, including the state-of-the-art technologies in advanced preclinical phases as well as those undergoing clinical trials, and assess their advantages and challenges. We also emphasize the importance of stimulus-responsive encapsulated cell systems that provide a “smart and live” therapeutic delivery to overcome barriers in cell transplantation as well as their use in patients.

Original languageEnglish (US)
Pages (from-to)92-115
Number of pages24
JournalAdvanced Drug Delivery Reviews
Volume139
DOIs
StatePublished - Jan 15 2019

PMID: 29719210

Altmetrics

Cite this

Standard

Cell encapsulation : Overcoming barriers in cell transplantation in diabetes and beyond. / Farina, M.; Alexander, Jenolyn F.; Thekkedath, Usha; Ferrari, Mauro; Grattoni, Alessandro.

In: Advanced Drug Delivery Reviews, Vol. 139, 15.01.2019, p. 92-115.

Research output: Contribution to journalReview article

Harvard

Farina, M, Alexander, JF, Thekkedath, U, Ferrari, M & Grattoni, A 2019, 'Cell encapsulation: Overcoming barriers in cell transplantation in diabetes and beyond' Advanced Drug Delivery Reviews, vol. 139, pp. 92-115. https://doi.org/10.1016/j.addr.2018.04.018

APA

Farina, M., Alexander, J. F., Thekkedath, U., Ferrari, M., & Grattoni, A. (2019). Cell encapsulation: Overcoming barriers in cell transplantation in diabetes and beyond. Advanced Drug Delivery Reviews, 139, 92-115. https://doi.org/10.1016/j.addr.2018.04.018

Vancouver

Farina M, Alexander JF, Thekkedath U, Ferrari M, Grattoni A. Cell encapsulation: Overcoming barriers in cell transplantation in diabetes and beyond. Advanced Drug Delivery Reviews. 2019 Jan 15;139:92-115. https://doi.org/10.1016/j.addr.2018.04.018

Author

Farina, M. ; Alexander, Jenolyn F. ; Thekkedath, Usha ; Ferrari, Mauro ; Grattoni, Alessandro. / Cell encapsulation : Overcoming barriers in cell transplantation in diabetes and beyond. In: Advanced Drug Delivery Reviews. 2019 ; Vol. 139. pp. 92-115.

BibTeX

@article{a8c917ca23274f169bb60a647d4806f1,
title = "Cell encapsulation: Overcoming barriers in cell transplantation in diabetes and beyond",
abstract = "Cell-based therapy is emerging as a promising strategy for treating a wide range of human diseases, such as diabetes, blood disorders, acute liver failure, spinal cord injury, and several types of cancer. Pancreatic islets, blood cells, hepatocytes, and stem cells are among the many cell types currently used for this strategy. The encapsulation of these “therapeutic” cells is under intense investigation to not only prevent immune rejection but also provide a controlled and supportive environment so they can function effectively. Some of the advanced encapsulation systems provide active agents to the cells and enable a complete retrieval of the graft in the case of an adverse body reaction. Here, we review various encapsulation strategies developed in academic and industrial settings, including the state-of-the-art technologies in advanced preclinical phases as well as those undergoing clinical trials, and assess their advantages and challenges. We also emphasize the importance of stimulus-responsive encapsulated cell systems that provide a “smart and live” therapeutic delivery to overcome barriers in cell transplantation as well as their use in patients.",
keywords = "3D printing, Cell-based therapy, Encapsulation system, Pancreatic islets, Stem cells",
author = "M. Farina and Alexander, {Jenolyn F.} and Usha Thekkedath and Mauro Ferrari and Alessandro Grattoni",
year = "2019",
month = "1",
day = "15",
doi = "10.1016/j.addr.2018.04.018",
language = "English (US)",
volume = "139",
pages = "92--115",
journal = "Advanced Drug Delivery Reviews",
issn = "0169-409X",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Cell encapsulation

T2 - Advanced Drug Delivery Reviews

AU - Farina, M.

AU - Alexander, Jenolyn F.

AU - Thekkedath, Usha

AU - Ferrari, Mauro

AU - Grattoni, Alessandro

PY - 2019/1/15

Y1 - 2019/1/15

N2 - Cell-based therapy is emerging as a promising strategy for treating a wide range of human diseases, such as diabetes, blood disorders, acute liver failure, spinal cord injury, and several types of cancer. Pancreatic islets, blood cells, hepatocytes, and stem cells are among the many cell types currently used for this strategy. The encapsulation of these “therapeutic” cells is under intense investigation to not only prevent immune rejection but also provide a controlled and supportive environment so they can function effectively. Some of the advanced encapsulation systems provide active agents to the cells and enable a complete retrieval of the graft in the case of an adverse body reaction. Here, we review various encapsulation strategies developed in academic and industrial settings, including the state-of-the-art technologies in advanced preclinical phases as well as those undergoing clinical trials, and assess their advantages and challenges. We also emphasize the importance of stimulus-responsive encapsulated cell systems that provide a “smart and live” therapeutic delivery to overcome barriers in cell transplantation as well as their use in patients.

AB - Cell-based therapy is emerging as a promising strategy for treating a wide range of human diseases, such as diabetes, blood disorders, acute liver failure, spinal cord injury, and several types of cancer. Pancreatic islets, blood cells, hepatocytes, and stem cells are among the many cell types currently used for this strategy. The encapsulation of these “therapeutic” cells is under intense investigation to not only prevent immune rejection but also provide a controlled and supportive environment so they can function effectively. Some of the advanced encapsulation systems provide active agents to the cells and enable a complete retrieval of the graft in the case of an adverse body reaction. Here, we review various encapsulation strategies developed in academic and industrial settings, including the state-of-the-art technologies in advanced preclinical phases as well as those undergoing clinical trials, and assess their advantages and challenges. We also emphasize the importance of stimulus-responsive encapsulated cell systems that provide a “smart and live” therapeutic delivery to overcome barriers in cell transplantation as well as their use in patients.

KW - 3D printing

KW - Cell-based therapy

KW - Encapsulation system

KW - Pancreatic islets

KW - Stem cells

UR - http://www.scopus.com/inward/record.url?scp=85044505756&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85044505756&partnerID=8YFLogxK

U2 - 10.1016/j.addr.2018.04.018

DO - 10.1016/j.addr.2018.04.018

M3 - Review article

VL - 139

SP - 92

EP - 115

JO - Advanced Drug Delivery Reviews

JF - Advanced Drug Delivery Reviews

SN - 0169-409X

ER -

ID: 39882785