Cell discrimination among simultaneous presentation of substrate-bound and soluble protein gradients

S. G. Ricoult, D. J. Lee, A. S. Ravan, Amy Q. Shen

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

To overcome the extracellular matrix's (ECM) complexity, cells rely on a plethora of cues to reach specific targets. Cues are concurrently presented to cells, and the cells must discriminate amongst these cues through a mechanism yet to be understood. To study cell navigation, in vitro methods have been developed to create gradients of single cues, such as substrate-bound or soluble proteins. Although insightful, these approaches lack the ability to present cells with multiple cues of various types. Here, we present a platform which for the first time enables the study of cell discrimination between soluble and substrate-bound protein gradients.

Original languageEnglish (US)
Title of host publicationMicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherChemical and Biological Microsystems Society
Pages680-682
Number of pages3
ISBN (Electronic)9780979806483
StatePublished - 2015
Event19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015 - Gyeongju, Korea, Republic of
Duration: Oct 25 2015Oct 29 2015

Other

Other19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015
CountryKorea, Republic of
CityGyeongju
Period10/25/1510/29/15

Keywords

  • Cell navigation
  • Chemotaxis
  • Digital nanodot gradient
  • Haptotaxis
  • Protein gradient

ASJC Scopus subject areas

  • Control and Systems Engineering

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