Abstract
To overcome the extracellular matrix's (ECM) complexity, cells rely on a plethora of cues to reach specific targets. Cues are concurrently presented to cells, and the cells must discriminate amongst these cues through a mechanism yet to be understood. To study cell navigation, in vitro methods have been developed to create gradients of single cues, such as substrate-bound or soluble proteins. Although insightful, these approaches lack the ability to present cells with multiple cues of various types. Here, we present a platform which for the first time enables the study of cell discrimination between soluble and substrate-bound protein gradients.
Original language | English (US) |
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Title of host publication | MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences |
Publisher | Chemical and Biological Microsystems Society |
Pages | 680-682 |
Number of pages | 3 |
ISBN (Electronic) | 9780979806483 |
State | Published - 2015 |
Event | 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015 - Gyeongju, Korea, Republic of Duration: Oct 25 2015 → Oct 29 2015 |
Other
Other | 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015 |
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Country/Territory | Korea, Republic of |
City | Gyeongju |
Period | 10/25/15 → 10/29/15 |
Keywords
- Cell navigation
- Chemotaxis
- Digital nanodot gradient
- Haptotaxis
- Protein gradient
ASJC Scopus subject areas
- Control and Systems Engineering