Cell-cell interactions in regulating lung function

Scott Boitano, Zeenat Safdar, Donald G. Welsh, Jahar Bhattacharya, Michael Koval

Research output: Contribution to journalReview articlepeer-review

44 Scopus citations


Tight junction barrier formation and gap junctional communication are two functions directly attributable to cell-cell contact sites. Epithelial and endothelial tight junctions are critical elements of the permeability barrier required to maintain discrete compartments in the lung. On the other hand, gap junctions enable a tissue to act as a cohesive unit by permitting metabolic coupling and enabling the direct transmission of small cytosolic signaling molecules from one cell to another. These components do not act in isolation since other junctional elements, such as adherens junctions, help regulate barrier function and gap junctional communication. Some fundamental elements related to regulation of pulmonary barrier function and gap junctional communication were presented in a Featured Topic session at the 2004 Experimental Biology Conference in Washington, DC, and are reviewed in this summary.

Original languageEnglish (US)
Pages (from-to)L455-L459
JournalAmerican Journal of Physiology - Lung Cellular and Molecular Physiology
Issue number3 31-3
StatePublished - Sep 2004


  • Cadherin
  • Calcium
  • Claudin
  • Connexin
  • Gap junction
  • Tight junction

ASJC Scopus subject areas

  • Physiology
  • Pulmonary and Respiratory Medicine
  • Physiology (medical)
  • Cell Biology


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