TY - JOUR
T1 - Cell Biology
T2 - Principles for the buffering of genetic variation
AU - Hartman IV, J. L.
AU - Garvik, B.
AU - Hartwell, L.
PY - 2001
Y1 - 2001
N2 - Most genetic research has used inbred organisms and has not explored the complexity of natural genetic variation present in outbred populations. The translation of genotype to phenotype is complicated by gene interactions observed as epistasis, canalization, robustness, or buffering. Analysis of double mutations in inbred experimental organisms suggests some principles for gene interaction that may apply to natural variation as well. The buffering of variation in one gene is most often due to a small number of other genes that function in the same biochemical process. However, buffering can also result from genes functioning in processes extrinsic to that of the primary gene.
AB - Most genetic research has used inbred organisms and has not explored the complexity of natural genetic variation present in outbred populations. The translation of genotype to phenotype is complicated by gene interactions observed as epistasis, canalization, robustness, or buffering. Analysis of double mutations in inbred experimental organisms suggests some principles for gene interaction that may apply to natural variation as well. The buffering of variation in one gene is most often due to a small number of other genes that function in the same biochemical process. However, buffering can also result from genes functioning in processes extrinsic to that of the primary gene.
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U2 - 10.1126/science.291.5506.1001
DO - 10.1126/science.291.5506.1001
M3 - Review article
C2 - 11232561
AN - SCOPUS:0035830860
VL - 291
SP - 1001
EP - 1004
JO - Science (New York, N.Y.)
JF - Science (New York, N.Y.)
SN - 0036-8075
IS - 5506
ER -