Celecoxib does not affect osteointegration of cementless total hip stems

David R. Lionberger, Jr., Philip C. Noble

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Celecoxib's effect on prosthetic osteointegration in patients undergoing total hip arthroplasty was studied. In a prospective, placebo-controlled, double-blind study of 49 patients, 24 were randomized to celecoxib (200 mg/d) and 25 to placebo over 6 weeks. Bone markers, N-teleopeptide, and bone-specific alkaline phosphatase were obtained postoperatively, and at 6 and 12 weeks. No radiographic prosthetic subsidence occurred. There were no significant differences from baseline in periprosthetic bone mineral density between the celecoxib and placebo groups at 3 and 6 months. There were no significant differences in baseline BSAlkP values between the 2 groups. At 6 and 12 weeks, average BSAlkP values increased. Urinary NTx concentrations followed a skewed distribution. Normalized NTx concentrations were statistically significantly greater in the celecoxib group than the placebo group at 6 weeks but not at 12 weeks.

Original languageEnglish (US)
Pages (from-to)115-122
Number of pages8
JournalJournal of Arthroplasty
Issue numberSUPPL. 3
StatePublished - Oct 2005


  • Bone mineral density
  • Celecoxib
  • N-telopeptide

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine


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