Ceftaroline-resistant, daptomycin-tolerant, and heterogeneous vancomycin-intermediate methicillin-resistant Staphylococcus aureus causing infective endocarditis

Masayuki Nigo, Lorena Diaz, Lina P. Carvajal, Truc T. Tran, Rafael Rios, Diana Panesso, Juan D. Garavito, William R. Miller, Audrey Wanger, George Weinstock, Jose M. Munita, Cesar A. Arias, Henry F. Chambers

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

We report a case of infective endocarditis (IE) caused by ceftaroline-resistant, daptomycin-tolerant, and heterogeneous vancomycin-intermediate methicillin-resistant S. aureus (MRSA). Resistance to ceftaroline emerged in the absence of drug exposure, and the E447K substitution in the active site of PBP2a previously associated with ceftaroline resistance was identified. Additionally, we present evidence of patient-to-patient transmission of the strain within the same unit. This case illustrates the difficulties in treating MRSA IE in the setting of a multidrug-resistant phenotype.

Original languageEnglish (US)
Article numbere01235
JournalAntimicrobial Agents and Chemotherapy
Volume61
Issue number3
DOIs
StatePublished - Mar 1 2017

Keywords

  • Ceftaroline
  • Endocarditis
  • Staphylococcus aureus

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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