CD36: A multiligand molecule

Yimin Ge, M. Tarek Elghetany

Research output: Contribution to journalReview article

35 Scopus citations

Abstract

CD36 is a multiligand receptor associated with a broad array of physiological processes and involved in markedly diverse disorders, including atherosclerosis, insulin resistance and diabetes, dyslipidemia, tumor angiogenesis, and host defense against Plasmodium falciparum. CD36 deficiency has proved to be common, particularly in ethnic groups such as African Americans and Asians. CD36 is commonly expressed on blasts in acute monocytic leukemia, megakaryoblastic leukemia, and erythroleukemia. The role of CD36 in sickle cell crises and cerebral malaria is debatable. As a receptor for thrombospondin 1, CD36 plays a role in the regulation of angiogenesis, which may be a therapeutic strategy for controlling the dissemination of malignant neoplasms. The future challenge will be to further understand the mechanisms by which CD36 affects these diverse functions and to design therapeutic strategies that can alter the course of the diseases. Lab Hematol.

Original languageEnglish (US)
Pages (from-to)31-37
Number of pages7
JournalLaboratory Hematology
Volume11
Issue number1
DOIs
StatePublished - Apr 14 2005

Keywords

  • CD36
  • Granulocytes
  • Leukemia
  • Thrombospondin receptor

ASJC Scopus subject areas

  • Hematology

Fingerprint Dive into the research topics of 'CD36: A multiligand molecule'. Together they form a unique fingerprint.

Cite this