TY - JOUR
T1 - CD30 antigen, a marker for Hodgkin's lymphoma, is a receptor whose ligand defines an emerging family of cytokines with homology to TNF
AU - Smith, Craig A.
AU - Gruss, Hans Juergen
AU - Davis, Terri
AU - Anderson, Dirk
AU - Farrah, Terry
AU - Baker, Elizabeth
AU - Sutherland, Grant R.
AU - Brannan, Camilynn I.
AU - Copeland, Neal G.
AU - Jenkins, Nancy A.
AU - Grabstein, Kenneth H.
AU - Gliniak, Brian
AU - McAlister, Ian B.
AU - Fanslow, William
AU - Alderson, Mark
AU - Falk, Ben
AU - Gimpel, Steve
AU - Gillis, Steven
AU - Din, Wenie S.
AU - Goodwin, Raymond G.
AU - Armitage, Richard J.
PY - 1993/7/2
Y1 - 1993/7/2
N2 - CD30 is a surface marker for neoplastic cells of Hodgkin's lymphoma and shows sequence homology to members of the tumor necrosis factor (TNF) receptor superfamily. Using a chimeric probe consisting of the extracellular domain of CD30 fused to truncated immunoglobulin heavy chains, we expression cloned the cDNA cognate from the murine T cell clone 7B9. The encoded protein is a 239 amino acid type II membrane protein whose C-terminal domain shows significant homology to TNFα, TNFβ, and the CD40L. Cross-hybridization to an induced peripheral blood T cell cDNA library yielded the human homolog, which is 72% identical at the amino acid level. The recombinant human ligand enhances the proliferation of CD3-activated T cells yet induces differential responses, including cell death, in several CD30+ lymphoma-derived clones. The human and murine genes map to 9q33 and the proximal region of chromosome 4, respectively.
AB - CD30 is a surface marker for neoplastic cells of Hodgkin's lymphoma and shows sequence homology to members of the tumor necrosis factor (TNF) receptor superfamily. Using a chimeric probe consisting of the extracellular domain of CD30 fused to truncated immunoglobulin heavy chains, we expression cloned the cDNA cognate from the murine T cell clone 7B9. The encoded protein is a 239 amino acid type II membrane protein whose C-terminal domain shows significant homology to TNFα, TNFβ, and the CD40L. Cross-hybridization to an induced peripheral blood T cell cDNA library yielded the human homolog, which is 72% identical at the amino acid level. The recombinant human ligand enhances the proliferation of CD3-activated T cells yet induces differential responses, including cell death, in several CD30+ lymphoma-derived clones. The human and murine genes map to 9q33 and the proximal region of chromosome 4, respectively.
UR - http://www.scopus.com/inward/record.url?scp=0027162651&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027162651&partnerID=8YFLogxK
U2 - 10.1016/0092-8674(93)90361-S
DO - 10.1016/0092-8674(93)90361-S
M3 - Article
C2 - 8391931
AN - SCOPUS:0027162651
VL - 73
SP - 1349
EP - 1360
JO - Cell
JF - Cell
SN - 0092-8674
IS - 7
ER -