CD30 antigen, a marker for Hodgkin's lymphoma, is a receptor whose ligand defines an emerging family of cytokines with homology to TNF

Craig A. Smith; Hans Juergen Gruss; Terri Davis; Dirk Anderson; Terry Farrah; Elizabeth Baker; Grant R. Sutherland; Camilynn I. Brannan; Neal G. Copeland; Nancy A. Jenkins; Kenneth H. Grabstein; Brian Gliniak; Ian B. McAlister; William Fanslow; Mark Alderson; Ben Falk; Steve Gimpel; Steven Gillis; Wenie S. Din; Raymond G. Goodwin; Richard J. Armitage

doi:10.1016/0092-8674(93)90361-S

CD30 antigen, a marker for Hodgkin's lymphoma, is a receptor whose ligand defines an emerging family of cytokines with homology to TNF

Craig A. Smith, Hans Juergen Gruss, Terri Davis, Dirk Anderson, Terry Farrah, Elizabeth Baker, Grant R. Sutherland, Camilynn I. Brannan, Neal G. Copeland, Nancy A. Jenkins, Kenneth H. Grabstein, Brian Gliniak, Ian B. McAlister, William Fanslow, Mark Alderson, Ben Falk, Steve Gimpel, Steven Gillis, Wenie S. Din, Raymond G. GoodwinRichard J. Armitage

Research output: Contribution to journal › Article › peer-review

506 Scopus citations

Abstract

CD30 is a surface marker for neoplastic cells of Hodgkin's lymphoma and shows sequence homology to members of the tumor necrosis factor (TNF) receptor superfamily. Using a chimeric probe consisting of the extracellular domain of CD30 fused to truncated immunoglobulin heavy chains, we expression cloned the cDNA cognate from the murine T cell clone 7B9. The encoded protein is a 239 amino acid type II membrane protein whose C-terminal domain shows significant homology to TNFα, TNFβ, and the CD40L. Cross-hybridization to an induced peripheral blood T cell cDNA library yielded the human homolog, which is 72% identical at the amino acid level. The recombinant human ligand enhances the proliferation of CD3-activated T cells yet induces differential responses, including cell death, in several CD30⁺ lymphoma-derived clones. The human and murine genes map to 9q33 and the proximal region of chromosome 4, respectively.

Original language	English (US)
Pages (from-to)	1349-1360
Number of pages	12
Journal	Cell
Volume	73
Issue number	7
DOIs	https://doi.org/10.1016/0092-8674(93)90361-S
State	Published - Jul 2 1993

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.1016/0092-8674(93)90361-S

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Smith, C. A., Gruss, H. J., Davis, T., Anderson, D., Farrah, T., Baker, E., Sutherland, G. R., Brannan, C. I., Copeland, N. G., Jenkins, N. A., Grabstein, K. H., Gliniak, B., McAlister, I. B., Fanslow, W., Alderson, M., Falk, B., Gimpel, S., Gillis, S., Din, W. S., ... Armitage, R. J. (1993). CD30 antigen, a marker for Hodgkin's lymphoma, is a receptor whose ligand defines an emerging family of cytokines with homology to TNF. Cell, 73(7), 1349-1360. https://doi.org/10.1016/0092-8674(93)90361-S

CD30 antigen, a marker for Hodgkin's lymphoma, is a receptor whose ligand defines an emerging family of cytokines with homology to TNF. / Smith, Craig A.; Gruss, Hans Juergen; Davis, Terri; Anderson, Dirk; Farrah, Terry; Baker, Elizabeth; Sutherland, Grant R.; Brannan, Camilynn I.; Copeland, Neal G.; Jenkins, Nancy A.; Grabstein, Kenneth H.; Gliniak, Brian; McAlister, Ian B.; Fanslow, William; Alderson, Mark; Falk, Ben; Gimpel, Steve; Gillis, Steven; Din, Wenie S.; Goodwin, Raymond G.; Armitage, Richard J.

In: Cell, Vol. 73, No. 7, 02.07.1993, p. 1349-1360.

Research output: Contribution to journal › Article › peer-review

Smith, CA, Gruss, HJ, Davis, T, Anderson, D, Farrah, T, Baker, E, Sutherland, GR, Brannan, CI, Copeland, NG , Jenkins, NA, Grabstein, KH, Gliniak, B, McAlister, IB, Fanslow, W, Alderson, M, Falk, B, Gimpel, S, Gillis, S, Din, WS, Goodwin, RG & Armitage, RJ 1993, 'CD30 antigen, a marker for Hodgkin's lymphoma, is a receptor whose ligand defines an emerging family of cytokines with homology to TNF', Cell, vol. 73, no. 7, pp. 1349-1360. https://doi.org/10.1016/0092-8674(93)90361-S

Smith, Craig A. ; Gruss, Hans Juergen ; Davis, Terri ; Anderson, Dirk ; Farrah, Terry ; Baker, Elizabeth ; Sutherland, Grant R. ; Brannan, Camilynn I. ; Copeland, Neal G. ; Jenkins, Nancy A. ; Grabstein, Kenneth H. ; Gliniak, Brian ; McAlister, Ian B. ; Fanslow, William ; Alderson, Mark ; Falk, Ben ; Gimpel, Steve ; Gillis, Steven ; Din, Wenie S. ; Goodwin, Raymond G. ; Armitage, Richard J. / CD30 antigen, a marker for Hodgkin's lymphoma, is a receptor whose ligand defines an emerging family of cytokines with homology to TNF. In: Cell. 1993 ; Vol. 73, No. 7. pp. 1349-1360.

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title = "CD30 antigen, a marker for Hodgkin's lymphoma, is a receptor whose ligand defines an emerging family of cytokines with homology to TNF",

abstract = "CD30 is a surface marker for neoplastic cells of Hodgkin's lymphoma and shows sequence homology to members of the tumor necrosis factor (TNF) receptor superfamily. Using a chimeric probe consisting of the extracellular domain of CD30 fused to truncated immunoglobulin heavy chains, we expression cloned the cDNA cognate from the murine T cell clone 7B9. The encoded protein is a 239 amino acid type II membrane protein whose C-terminal domain shows significant homology to TNFα, TNFβ, and the CD40L. Cross-hybridization to an induced peripheral blood T cell cDNA library yielded the human homolog, which is 72% identical at the amino acid level. The recombinant human ligand enhances the proliferation of CD3-activated T cells yet induces differential responses, including cell death, in several CD30+ lymphoma-derived clones. The human and murine genes map to 9q33 and the proximal region of chromosome 4, respectively.",

author = "Smith, {Craig A.} and Gruss, {Hans Juergen} and Terri Davis and Dirk Anderson and Terry Farrah and Elizabeth Baker and Sutherland, {Grant R.} and Brannan, {Camilynn I.} and Copeland, {Neal G.} and Jenkins, {Nancy A.} and Grabstein, {Kenneth H.} and Brian Gliniak and McAlister, {Ian B.} and William Fanslow and Mark Alderson and Ben Falk and Steve Gimpel and Steven Gillis and Din, {Wenie S.} and Goodwin, {Raymond G.} and Armitage, {Richard J.}",

note = "Funding Information: We thank Kurt Shanebeck and Debra J. Gilbert for excellent technical assistance and Dave Cosman and John Sims for critical review of the manuscript. The murine chromosomal mapping was supported in part by the National Cancer Institute, Department of Health and Human Services, under contract NOl-CO-74101 with Advanced Bioscience Laboratory. Copyright: Copyright 2015 Elsevier B.V., All rights reserved.",

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AU - Farrah, Terry

AU - Baker, Elizabeth

AU - Sutherland, Grant R.

AU - Brannan, Camilynn I.

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AU - Jenkins, Nancy A.

AU - Grabstein, Kenneth H.

AU - Gliniak, Brian

AU - McAlister, Ian B.

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AU - Falk, Ben

AU - Gimpel, Steve

AU - Gillis, Steven

AU - Din, Wenie S.

AU - Goodwin, Raymond G.

AU - Armitage, Richard J.

N1 - Funding Information: We thank Kurt Shanebeck and Debra J. Gilbert for excellent technical assistance and Dave Cosman and John Sims for critical review of the manuscript. The murine chromosomal mapping was supported in part by the National Cancer Institute, Department of Health and Human Services, under contract NOl-CO-74101 with Advanced Bioscience Laboratory. Copyright: Copyright 2015 Elsevier B.V., All rights reserved.

PY - 1993/7/2

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N2 - CD30 is a surface marker for neoplastic cells of Hodgkin's lymphoma and shows sequence homology to members of the tumor necrosis factor (TNF) receptor superfamily. Using a chimeric probe consisting of the extracellular domain of CD30 fused to truncated immunoglobulin heavy chains, we expression cloned the cDNA cognate from the murine T cell clone 7B9. The encoded protein is a 239 amino acid type II membrane protein whose C-terminal domain shows significant homology to TNFα, TNFβ, and the CD40L. Cross-hybridization to an induced peripheral blood T cell cDNA library yielded the human homolog, which is 72% identical at the amino acid level. The recombinant human ligand enhances the proliferation of CD3-activated T cells yet induces differential responses, including cell death, in several CD30+ lymphoma-derived clones. The human and murine genes map to 9q33 and the proximal region of chromosome 4, respectively.

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CD30 antigen, a marker for Hodgkin's lymphoma, is a receptor whose ligand defines an emerging family of cytokines with homology to TNF

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