CD28-negative CD4 + and CD8 + T cells in antiretroviral therapy-naive HIV-infected adults enrolled in adult clinical trials group studies

Katherine Tassiopoulos, Alan Landay, Ann C. Collier, Elizabeth Connick, Steven G. Deeks, Peter Hunt, Dorothy E. Lewis, Cara Wilson, Ronald Bosch

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

Background Individuals infected with human immunodeficiency virus (HIV) have higher risk than HIV-negative individuals for diseases associated with aging. T-cell senescence, characterized by expansion of cells lacking the costimulatory molecule CD28, has been hypothesized to mediate these risks.MethodsWe measured the percentage of CD28 -CD4 + and CD8 + T cells from HIV-infected treatment-naive adults from 5 Adult Clinical Trials Group (ACTG) antiretroviral therapy (ART) studies and the ALLRT (ACTG Longitudinal Linked Randomized Trials) cohort, and from 48 HIV-negative adults. Pretreatment and 96-week posttreatment CD28 - cells were assessed using linear regression for associations with age, sex, race/ethnicity, CD4 count, HIV RNA, ART regimen, and hepatitis C virus (HCV) infection.ResultsIn total, 1291 chronically HIV-infected adults were studied. Pretreatment, lower CD4 count was associated with higher CD28 -CD4 + and CD28 -CD8 + cells. For CD8 + cells, younger age and HCV infection were associated with a lower CD28 -. ART reduced CD28 - levels at week 96 among virally suppressed individuals. Older age was strongly predictive of higher CD28 -CD8 +. Compared to HIV-uninfected individuals, HIV-infected individuals maintained significantly higher CD28 -. Conclusions Effective ART reduced the proportion of CD28 - T cells. However, levels remained abnormally high and closer to levels in older HIV-uninfected individuals. This finding may inform future research of increased rates of age-associated disease in HIV-infected adults.

Original languageEnglish (US)
Pages (from-to)1730-1738
Number of pages9
JournalJournal of Infectious Diseases
Volume205
Issue number11
DOIs
StatePublished - Jun 1 2012

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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