CD2-negative lymphoma-associated T-cells: a potential mechanism of immune-evasion in diffuse large B-cell lymphoma

Anindita Ghosh, Mario L. Marques-Piubelli, Xiaoqiong Wang, Tiffany G. Sheu, Joanne Cheng, Khaja Khan, Wei Lu, John Manning, Guilin Tang, Luisa M. Solis, Francisco Vega

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

CD2 is a costimulatory protein expressed in all mature T/NK-cells, in particular memory T-cells. CD58 (or LFA-3) is the receptor for CD2 and is ubiquitously expressed. CD2-CD58 interaction has key functions in T-cell activation and organization of the immunological synapse between T- and antigen-presenting cells. Cancer cells have developed multiple mechanisms to evade immune surveillance. Loss of CD58 expression is one frequently reported in diffuse large B-cell lymphomas (DLBCL). On the other hand, in non-hematological neoplasms, tumor infiltrating lymphocytes (TILs) with reduced expression of CD2 have been associated with defective cytotoxicity and T-cell exhaustion. Here, we reported a case of DLBCL involving the jejunal mucosa associated with a rim of cytotoxic reactive T-cells with features of immune evasion (CD2- and TCR-) and T-cell exhaustion (PD1 + high). This case likely exemplifies a previously unrecognized immune evasion mechanism in lymphoma involving a decreased CD2 expression in the lymphoma-associated T-cells.

Original languageEnglish (US)
Pages (from-to)659-663
Number of pages5
JournalVirchows Archiv
Volume481
Issue number4
DOIs
StatePublished - Oct 2022

Keywords

  • CD2
  • CD58
  • Diffuse large B-cell lymphoma
  • Immune evasion
  • Lymphoma-associated lymphoid cells

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Biology
  • Cell Biology

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