@article{6ca306020fd24989af7099efc9706ec9,
title = "Causes of death in intermediate-risk patients: The Randomized Surgical Replacement and Transcatheter Aortic Valve Implantation Trial",
abstract = "Objectives: Examine the causes and timing of death in the Surgical Replacement and Transcatheter Aortic Valve Implantation intermediate-risk randomized trial for transcatheter aortic valve replacement (TAVR) and surgical aortic valve replacement (SAVR). Methods: Causes of death were adjudicated by an independent clinical event committee and by post-hoc hierarchical classification. Causes of death were evaluated and characteristics and procedural parameters compared between patients who died and survivors for 3 time periods: early (0-30 days), recovery (31-120 days), and late (121-365 days). Results: All-cause mortality at 1 year was 6.5% after TAVR and 6.7% after SAVR. There were no differences in mortality rates between TAVR and SAVR for any of the 3 time periods. Early mortality was primarily due to technical, procedure-related problems in TAVR and due to complications in SAVR. For TAVR and SAVR, most deaths during recovery were caused by complications. Other causes, including comorbid conditions, accounted for most late deaths. Conclusions: Mortality rates were similar for patients treated with TAVR or SAVR at any time period including at 1 year. Early cause of death was more commonly technical failure after TAVR and due to complications after SAVR. Recovery phase cause of death was dominated by complications from TAVR and SAVR. Late cause of death appeared to be independent of the procedure in both groups.",
keywords = "causes of death, intermediate risk, surgical aortic valve replacement, transcatheter aortic valve replacement",
author = "{SURTAVI Trial Causes of Death Working Group} and Hafid Amrane and Deeb, {G. Michael} and Popma, {Jeffrey J.} and Yakubov, {Steven J.} and Gleason, {Thomas G.} and {Van Mieghem}, {Nicolas M.} and Reardon, {Michael J.} and Williams, {Mathew R.} and Mubashir Mumtaz and Kappetein, {Arie Pieter} and Serruys, {Patrick W.} and Peter Tadros and Zorn, {George L.} and Boonstra, {Piet W.} and {van Boven}, Ad and Shuzhen Li",
note = "Funding Information: Funding for this study was provided by Medtronic, Minneapolis, Minn.Dr Amrane serves as a consultant to Abbott and has received research grants from Medtronic and Abbott. Dr Deeb serves as on an advisory board and as a proctor for Medtronic, as a consultant and research investigator for Edwards Lifesciences, as a consultant and proctor for Terumo, and as a research investigator for Gore Medical. He receives no personal remunerations. Dr Williams serves as a consultant for Edwards Lifesciences and Medtronic, as a speaker for Abbott Laboratories, and has received research grants from Medtronic. Dr Popma has received institutional research grants from Medtronic, Boston Scientific, and Direct Flow Medical, and has served on a Medical Advisory Board for Boston Scientific, Cordis Corporation, and Edwards Lifesciences. Dr Mumtaz has served as a proctor, served as a consultant, and received honoraria, consulting fees, and travel reimbursements from Medtronic, Abbott, Edwards Lifesciences, and Atricure. Dr Kappetein is an employee of Medtronic. Dr Yakubov has received institutional research grants from Boston Scientific, Direct Flow, and Medtronic. Dr Van Mieghem has received grant support from Abbott Vascular, Boston Scientific, Claret Medical, and Medtronic. Dr Gleason receives institutional grant support from Medtronic but receives no personal income. Dr Serruys receives personal fees from Abbott Laboratories, AstraZeneca, Biotronik, Cardialysis, GLG research, Medtronic, Sino Medical Sciences Technology, and Societe Europa Digital Publishing, Stentys Fran, Svellte Medical Systems, Philips/Volcano, St Jude Medical and Qualimed. Dr Tadros discloses a financial relationship with Medtronic and St. Jude Medical. Dr Zorn has a financial relationship with Medtronic and Edwards Lifesciences. Dr Li is an employee and shareholder of Medtronic. Dr Reardon has received fees from Medtronic for providing educational services. All other authors have nothing to disclose with regard to commercial support. Jane Moore, MS, ELS, an employee of the sponsor, created all figures and tables, and drafted the introduction, methods, and results sections under the direction of Drs Amrane and Reardon, and ensured the technical accuracy of the information presented. Members of the SURTAVI Trial Causes of Death Working Group include Mathew R. Williams, MD (New York University-Langone Medical Center, New York, NY); Mubashir Mumtaz, MD (University of Pittsburg Medical Center Pinnacle, Wormsleyburg, Pa); Arie Pieter Kappetein, MD, PhD (Erasmus Medical Center, Rotterdam, the Netherlands); Patrick W. Serruys, MD, PhD (International Centre for Circulatory Health, National Heart Lung Institute, Imperial College London, London, United Kingdom); Peter Tadros, MD, and George L. Zorn III, MD (University of Kansas, Kansas City, Kan); Piet W. Boonstra, MD, and Ad van Boven, MD (Medisch Centrum Leeuwarden, the Netherlands); and Shuzhen Li, PhD (Statistical Services, Medtronic, Minneapolis, Minn). Funding Information: Funding for this study was provided by Medtronic , Minneapolis, Minn. Funding Information: Dr Amrane serves as a consultant to Abbott and has received research grants from Medtronic and Abbott . Dr Deeb serves as on an advisory board and as a proctor for Medtronic, as a consultant and research investigator for Edwards Lifesciences, as a consultant and proctor for Terumo, and as a research investigator for Gore Medical. He receives no personal remunerations. Dr Williams serves as a consultant for Edwards Lifesciences and Medtronic, as a speaker for Abbott Laboratories, and has received research grants from Medtronic . Dr Popma has received institutional research grants from Medtronic , Boston Scientific , and Direct Flow Medical , and has served on a Medical Advisory Board for Boston Scientific, Cordis Corporation, and Edwards Lifesciences. Dr Mumtaz has served as a proctor, served as a consultant, and received honoraria, consulting fees, and travel reimbursements from Medtronic, Abbott, Edwards Lifesciences, and Atricure. Dr Kappetein is an employee of Medtronic. Dr Yakubov has received institutional research grants from Boston Scientific , Direct Flow , and Medtronic . Dr Van Mieghem has received grant support from Abbott Vascular , Boston Scientific , Claret Medical , and Medtronic . Dr Gleason receives institutional grant support from Medtronic but receives no personal income. Dr Serruys receives personal fees from Abbott Laboratories, AstraZeneca, Biotronik, Cardialysis, GLG research, Medtronic, Sino Medical Sciences Technology, and Societe Europa Digital Publishing, Stentys Fran, Svellte Medical Systems, Philips/Volcano, St Jude Medical and Qualimed. Dr Tadros discloses a financial relationship with Medtronic and St. Jude Medical . Dr Zorn has a financial relationship with Medtronic and Edwards Lifesciences . Dr Li is an employee and shareholder of Medtronic. Dr Reardon has received fees from Medtronic for providing educational services. All other authors have nothing to disclose with regard to commercial support. Publisher Copyright: {\textcopyright} 2018 The American Association for Thoracic Surgery",
year = "2019",
month = sep,
doi = "10.1016/j.jtcvs.2018.11.129",
language = "English (US)",
volume = "158",
pages = "718--728.e3",
journal = "Journal of Thoracic and Cardiovascular Surgery",
issn = "0022-5223",
publisher = "Mosby Inc.",
number = "3",
}