Caspase-10 is an initiator caspase in death receptor signaling

Jin Wang, Hyung J. Chun, Wilson Wong, David M. Spencer, Michael J. Lenardo

Research output: Contribution to journalArticle

289 Scopus citations

Abstract

A role for caspase-10, previously implicated in the autoimmune lymphoproliferative syndrome, in death receptor signaling has not been directly shown. Here we show that caspase-10 can function independently of caspase-8 in initiating Fas- and tumor necrosis factor-related apoptosis-inducing ligand-receptor-mediated apoptosis. Moreover, Fas crosslinking in primary human T cells leads to the recruitment and activation of caspase-10. Fluorescent resonance energy transfer analysis indicates that the death-effector domains of caspase-8 and -10 both interact with the death-effector domain of FADD. Nonetheless, we find that caspase-8 and -10 may have different apoptosis substrates and therefore potentially distinct roles in death receptor signaling or other cellular processes.

Original languageEnglish (US)
Pages (from-to)13884-13888
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume98
Issue number24
DOIs
StatePublished - Nov 20 2001

ASJC Scopus subject areas

  • General

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