Case Study: Application of LeukoLike Technology to Camouflage Nanoparticles from the Immune Recognition: Application of leukoLike technology to camouflage nanoparticles from the immune recognition

Naama E. Toledano Furman, Roberto Molinaro, Alessandro Parodi, Michael Evangelopoulos, Johnathan Martinez, Claudia Corbo, Roberto Palomba, Iman K. Yazdi, Ennio Tasciotti

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The ability of nanoparticles to evade the immune system, cross biological barriers, and localize at the target tissue ultimately determines their therapeutic potential. Leukocytes naturally encompass all of these features and, therefore, provide great inspiration in biomimetic vectors. Herein, we present a hybrid drug delivery system, termed leukolike vectors, composed of a synthetic nanoporous silicon core cloaked with cellular membranes derived from circulating white blood cells. These particles possess the ability to avoid clearance by the mononuclear phagocyte system, interact with endothelial cells through receptor-ligand interaction, and effi ciently deliver a therapeutic payload to infl amed endothelia. Furthermore, in vivo studies revealed an ability to retain the leukocyte membrane's biological function following systemic administration, demonstrating prolonged circulation and improved tumor targeting abilities.

Original languageEnglish (US)
Title of host publicationHandbook of Immunological Properties of Engineered Nanomaterials
Subtitle of host publicationEngineered Nanomaterials and the Immune Cell Function
EditorsMarina A Dobrovolskaia, Scott E McNeil
PublisherWorld Scientific Publishing Co. Pte Ltd
Pages43-68
Number of pages26
Volume3
Edition2nd
ISBN (Electronic)978-981-4699-18-1
ISBN (Print)978-981-4699-16-7
DOIs
StatePublished - Apr 1 2016

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology and Microbiology(all)
  • Engineering(all)

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