Case Series Description and Genomic Characterization of Invasive Group A Streptococcal Infections in Pediatric Patients

Jennifer Dien Bard; Kanokporn Mongkolrattanothai; Priyanka Kachroo; Stephen Beres; Randall J Olsen

doi:10.1097/INF.0000000000001519

Case Series Description and Genomic Characterization of Invasive Group A Streptococcal Infections in Pediatric Patients

Jennifer Dien Bard, Kanokporn Mongkolrattanothai, Priyanka Kachroo, Stephen Beres, Randall J Olsen

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

We report an unusual cluster of invasive group A Streptococcus (GAS) infections in six pediatric patients and demonstrate that the strains were derived from diverse genetic backgrounds, confirming the occurrence of a community cluster rather than a clonal outbreak. Whole genome sequencing provided a rapid and comprehensive view of GAS genotypes, and helped guide our institutional response and public health maneuvers.

Original language	English (US)
Journal	Pediatric Infectious Disease Journal
DOIs	https://doi.org/10.1097/INF.0000000000001519
State	Published - Dec 27 2016

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title = "Case Series Description and Genomic Characterization of Invasive Group A Streptococcal Infections in Pediatric Patients",

abstract = "We report an unusual cluster of invasive group A Streptococcus (GAS) infections in six pediatric patients and demonstrate that the strains were derived from diverse genetic backgrounds, confirming the occurrence of a community cluster rather than a clonal outbreak. Whole genome sequencing provided a rapid and comprehensive view of GAS genotypes, and helped guide our institutional response and public health maneuvers.",

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AU - Bard, Jennifer Dien

AU - Mongkolrattanothai, Kanokporn

AU - Kachroo, Priyanka

AU - Beres, Stephen

AU - Olsen, Randall J

PY - 2016/12/27

Y1 - 2016/12/27

N2 - We report an unusual cluster of invasive group A Streptococcus (GAS) infections in six pediatric patients and demonstrate that the strains were derived from diverse genetic backgrounds, confirming the occurrence of a community cluster rather than a clonal outbreak. Whole genome sequencing provided a rapid and comprehensive view of GAS genotypes, and helped guide our institutional response and public health maneuvers.

AB - We report an unusual cluster of invasive group A Streptococcus (GAS) infections in six pediatric patients and demonstrate that the strains were derived from diverse genetic backgrounds, confirming the occurrence of a community cluster rather than a clonal outbreak. Whole genome sequencing provided a rapid and comprehensive view of GAS genotypes, and helped guide our institutional response and public health maneuvers.

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DO - 10.1097/INF.0000000000001519

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SN - 0891-3668

JO - Pediatric Infectious Disease Journal

JF - Pediatric Infectious Disease Journal

ER -

Case Series Description and Genomic Characterization of Invasive Group A Streptococcal Infections in Pediatric Patients

Abstract

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