Case Commentary: A herculean effort for Mycobacterium heraklionense—localized azithromycin bead pharmacokinetics

Shemual Tsai; Kevin Grimes

doi:10.1128/aac.00305-25

Case Commentary: A herculean effort for Mycobacterium heraklionense—localized azithromycin bead pharmacokinetics

Research output: Contribution to journal › Review article › peer-review

Abstract

Non-tuberculous mycobacterial infections present significant treatment challenges due to resistance and limited data on optimal antibiotic regimens. A recently published case report provided an innovative approach to Mycobacterium heraklionese hand tenosynovitis with azithromycin-loaded calcium sulfate beads and valuable pharmacokinetic data with concentration measurements. This case demonstrates the ability of azithromycin-loaded calcium sulfate beads to achieve high local tissue concentrations with low systemic toxicity.

Original language	English (US)
Journal	Antimicrobial Agents and Chemotherapy
Volume	69
Issue number	6
DOIs	https://doi.org/10.1128/aac.00305-25
State	Published - Jun 2025

Keywords

azithromycin
calcium sulfate beads
localized antibiotics
mycobacterium
nontuberculous mycobacteria
pharmacokinetics

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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10.1128/aac.00305-25

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title = "Case Commentary: A herculean effort for Mycobacterium heraklionense—localized azithromycin bead pharmacokinetics",

abstract = "Non-tuberculous mycobacterial infections present significant treatment challenges due to resistance and limited data on optimal antibiotic regimens. A recently published case report provided an innovative approach to Mycobacterium heraklionese hand tenosynovitis with azithromycin-loaded calcium sulfate beads and valuable pharmacokinetic data with concentration measurements. This case demonstrates the ability of azithromycin-loaded calcium sulfate beads to achieve high local tissue concentrations with low systemic toxicity.",

keywords = "azithromycin, calcium sulfate beads, localized antibiotics, mycobacterium, nontuberculous mycobacteria, pharmacokinetics",

author = "Shemual Tsai and Kevin Grimes",

note = "Publisher Copyright: Copyright {\textcopyright} 2025 Tsai and Grimes.",

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language = "English (US)",

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AU - Grimes, Kevin

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KW - calcium sulfate beads

KW - localized antibiotics

KW - mycobacterium

KW - nontuberculous mycobacteria

KW - pharmacokinetics

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Case Commentary: A herculean effort for Mycobacterium heraklionense—localized azithromycin bead pharmacokinetics

Abstract

Keywords

ASJC Scopus subject areas

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