Carotid Artery Stenosis—Hemodynamic Significance and Clinical Course

Ronald W. Busuttil, Herbert I. Machleder, Robin K. Davidson

Research output: Contribution to journalArticlepeer-review

112 Scopus citations


Two hundred fifteen patients with a history of either stroke, transient ischemic attack (TIA), or asymptomatic carotid bruit underwent noninvasive carotid artery testing using oculopneumoplethysmography. Of patients with hemodynamically significant stenosis, 51 (40.8%) underwent endarterectomy, and 74 (59.2%) were treated nonoperatively. The incidence of stroke in the nonoperated group was 12/74 (16.2%) compared with only 1/51 (1.9%) in the operated group. Similarly, recurrent TIA occurred in 29/74 (39.2%) of the nonoperated group vs 9/51 (17.6%) of the operated. In nonhemodynamically significant carotid stenosis, the risk of cerebrovascular death and stroke was exceedingly low: 2/90 (2.2%). Patients with hemodynamically significant stenosis treated nonoperatively have a greater risk of cerebrovascular death, stroke, and TIA than patients treated with carotid endarterectomy.

Original languageEnglish (US)
Pages (from-to)1438-1441
Number of pages4
JournalJAMA: The Journal of the American Medical Association
Issue number14
StatePublished - Apr 10 1981

ASJC Scopus subject areas

  • Medicine(all)


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