19 Scopus citations


Proton pump inhibitors (PPIs) are effective agents for the treatment of gastroesophageal reflux (GERD). However, these drugs have not been approved for long-term use. Now sold over the counter, these agents are being used chronically for GERD without medical supervision. The long-term use of PPIs may have significant adverse effects, in part mediated by their effect of accelerating vascular aging. Physicians should assist patients in tapering off their use of PPIs and replacing them with lifestyle modifications and/or other agents that have better long-term safety profiles.

Original languageEnglish (US)
Pages (from-to)214-219
Number of pages6
JournalMethodist DeBakey cardiovascular journal
Issue number3
StatePublished - Jul 1 2019


  • gastroesophageal reflux disease
  • GERD
  • H2 antagonists
  • proton pump inhibitor

ASJC Scopus subject areas

  • Medicine(all)


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