Cardiovascular Effects of Exposure to Cigarette Smoke and Electronic Cigarettes: Clinical Perspectives from the Prevention of Cardiovascular Disease Section Leadership Council and Early Career Councils of the American College of Cardiology

Pamela B. Morris, Brian A. Ference, Eiman Jahangir, Dmitriy N. Feldman, John J. Ryan, Hossein Bahrami, Mikhael F. El-Chami, Shyam Bhakta, David E. Winchester, Mouaz H. Al-Mallah, Monica Sanchez Shields, Prakash Deedwania, Laxmi S. Mehta, Binh An P. Phan, Neal L. Benowitz

Research output: Contribution to journalReview article

96 Scopus citations

Abstract

Cardiovascular morbidity and mortality as a result of inhaled tobacco products continues to be a global healthcare crisis, particularly in low- and middle-income nations lacking the infrastructure to develop and implement effective public health policies limiting tobacco use. Following initiation of public awareness campaigns 50 years ago in the United States, considerable success has been achieved in reducing the prevalence of cigarette smoking and exposure to secondhand smoke. However, there has been a slowing of cessation rates in the United States during recent years, possibly caused by high residual addiction or fatigue from cessation messaging. Furthermore, tobacco products have continued to evolve faster than the scientific understanding of their biological effects. This review considers selected updates on the genetics and epigenetics of smoking behavior and associated cardiovascular risk, mechanisms of atherogenesis and thrombosis, clinical effects of smoking and benefits of cessation, and potential impact of electronic cigarettes on cardiovascular health.

Original languageEnglish (US)
Pages (from-to)1378-1391
Number of pages14
JournalJournal of the American College of Cardiology
Volume66
Issue number12
DOIs
StatePublished - Sep 22 2015

Keywords

  • Key Words atherogenesis
  • genetic and epigenetic effects
  • smoke-free legislation
  • thrombosis
  • tobacco cessation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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