Cardiovascular Disease in Acromegaly

Morali D Sharma, Anh V Nguyen, Spandana Brown, Richard J Robbins

Research output: Contribution to journalArticlepeer-review

31 Scopus citations


In patients with acromegaly, chronic excess of growth hormone (GH) and insulin-like growth factor-1 (IGF-1) leads to the development of acromegalic cardiomyopathy. Its main features are biventricular hypertrophy, diastolic dysfunction, and in later stages, systolic dysfunction and congestive heart failure. Surgical and/or pharmacological treatment of acromegaly and control of cardiovascular risk factors help reverse some of these pathophysiologic changes and decrease the high risk of cardiovascular complications.

Original languageEnglish (US)
Pages (from-to)64-67
Number of pages4
JournalMethodist DeBakey cardiovascular journal
Issue number2
StatePublished - Jul 26 2017


  • Journal Article


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